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Acetylcholine induced endothelial-dependent vasodilation increases as artery diameter decreases in the rabbit ear

Summary

Isolated resistance vessels in the rabbit ear preconstricted with histamine were relaxed by acetylcholine by a proportionately greater amount than the central ear artery. The relaxation was antagonized by atropine and also by endothelium removal. Our studies represent the first direct evidence that endothelium-dependent dilation can occur in resistance vessels.

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Acknowledgments. We thank Christine Quinn for her careful technical assistance in the use of the myographs and Daniel Netto for construction of the small vessel myographs. The tungsten wire used for mounting the vessels was given by Westinghouse Corporation Lamp Division. This work was supported by American Heart Association Fellowship 608 and National Heart, Lung, and Blood Institute Grant HL-32985.

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Owen, M.P., Bevan, J.A. Acetylcholine induced endothelial-dependent vasodilation increases as artery diameter decreases in the rabbit ear. Experientia 41, 1057–1058 (1985). https://doi.org/10.1007/BF01952142

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  • DOI: https://doi.org/10.1007/BF01952142

Key words

  • Acetylcholine
  • endothelium-dependent vasodilation
  • resistance vessel