, Volume 41, Issue 8, pp 1057–1058 | Cite as

Acetylcholine induced endothelial-dependent vasodilation increases as artery diameter decreases in the rabbit ear

  • M. P. Owen
  • J. A. Bevan


Isolated resistance vessels in the rabbit ear preconstricted with histamine were relaxed by acetylcholine by a proportionately greater amount than the central ear artery. The relaxation was antagonized by atropine and also by endothelium removal. Our studies represent the first direct evidence that endothelium-dependent dilation can occur in resistance vessels.

Key words

Acetylcholine endothelium-dependent vasodilation resistance vessel 


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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • M. P. Owen
    • 1
  • J. A. Bevan
    • 1
  1. 1.Department of PharmacologyUniversity of Vermont, College of MedicineBurlingtonUSA

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