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Experientia

, Volume 41, Issue 8, pp 1057–1058 | Cite as

Acetylcholine induced endothelial-dependent vasodilation increases as artery diameter decreases in the rabbit ear

  • M. P. Owen
  • J. A. Bevan
Article

Summary

Isolated resistance vessels in the rabbit ear preconstricted with histamine were relaxed by acetylcholine by a proportionately greater amount than the central ear artery. The relaxation was antagonized by atropine and also by endothelium removal. Our studies represent the first direct evidence that endothelium-dependent dilation can occur in resistance vessels.

Key words

Acetylcholine endothelium-dependent vasodilation resistance vessel 

References

  1. 1.
    Furchgott, R.F., and Zawadzki, J.V., Nature288 (1980) 373.Google Scholar
  2. 2.
    Owen, M.P., Walmsley, J.G., Mason, M.F., Bevan, R.D., and Bevan, J.A., Am. J. Physiol.245 (1983) H320.Google Scholar
  3. 3.
    Bevan, J.A., and Osher, J.V., Agents Actions2 (1972) 257.Google Scholar
  4. 4.
    Mulvany, M.J., and Halpern, W., Nature260 (1976) 617.Google Scholar
  5. 5.
    Brayden, J.E., and Bevan, J.A., Fedn Proc.43 (1984) 404.Google Scholar
  6. 6.
    Rhodin, J.A.G., in: Handbook of Physiology. The Cardiovascular System, vol. 2, p. 1. Eds D.F. Bohr, A.P. Somlyo and H.V. Sparks, Jr. Am. Physiol. Soc./Bethesda, Maryland 1980.Google Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • M. P. Owen
    • 1
  • J. A. Bevan
    • 1
  1. 1.Department of PharmacologyUniversity of Vermont, College of MedicineBurlingtonUSA

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