Advertisement

Experientia

, Volume 41, Issue 8, pp 1042–1045 | Cite as

Effect of coenzyme-A, NAD, alpha lipoic-acid and cocarboxylase on survival of rats with galactosamine-induced severe hepatitis

  • H. Thölen
  • W. Zimmerli
  • Z. Rajacic
Article

Summary

Galactosamine, a selective hepatotoxin, produces in rats histologic alterations, which show the characteristics of severe human viral hepatitis. In the present study the efficacy of two different cofactor regimens (coenzyme A, NAD, alpha lipoic-acid, cocarboxylase) in rats with fulminant galactosamine hepatitis were tested. The results showed an improvement of the short-term survival with a short-term treatment and definitely better survival with a long-term regimen with cofactors.

Key words

Liver failure hepatitis galactosamine coenzyme A NAD 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Thölen, H. and Bigler, F., Dt. med. Wschr.87 (1962) 1188.Google Scholar
  2. 2.
    Thölen, H., Ergebn. inn. Med. Kinderheilk.21 (1964) 49.Google Scholar
  3. 3.
    Krebs, H. A., and Johnson, W. H., Enzymologia4 (1937) 148.Google Scholar
  4. 4.
    Bigler, F., Thölen, H., and Staub, H., Schw. med., Wschr.92 (1962) 746.Google Scholar
  5. 5.
    Thölen, H., Bigler, F., Heusler, A., and Staub, H., Dt. med. Wschr.87 (1962) 2488.Google Scholar
  6. 6.
    Schmidlin, O., Zur Therapie des endogenen Lebercomas. Inaug. Diss., Basel 1977.Google Scholar
  7. 7.
    Trey, C., Lipworth, L., and Davidson, C. S., Gastroenterology58 (1970) 306.Google Scholar
  8. 8.
    Keppler, D., Lesch, R., Reutter, W., and Decker, K., Exp. molec. Path.9 (1968) 279.Google Scholar
  9. 9.
    Gröflin, U. B., and Thölen, H., Experientia34 (1978) 1501.Google Scholar
  10. 10.
    Gröflin, U. B., Hirnödem bei der Galaktosaminhepatitis der Ratte. Inaug. Diss., Basel 1982.Google Scholar
  11. 11.
    Zimmerli, W., Grubinger, Ch., Thölen, H., Oberholzer, M., and Bianchi, L., Experientia37 (1981) 1323.Google Scholar
  12. 12.
    Blitzer, B. L., Waggoner, J. G., Jones, E. A., Gralnick, H. R., Towne, D., Butler, J., Weise, V., Kopin, I. J., Walter, I., Teychenne, P. F., Goodman, D. G., and Berk, P. D. Gastroenterology74 (1978) 664.Google Scholar
  13. 13.
    Engberg, A., Acta physiol. scand.75 (1969) 170.Google Scholar
  14. 14.
    Thiel, G., Brunner, F., Wunderlich, P., Huguenin, M., Bienko, B., Torhorst, J., Peters-Häfeli, L., Kirchhertz, E. J., and Peters, G., Kidney Int. Suppl.6 (1976) 191.Google Scholar
  15. 15.
    Gimson, A. E. S., Braude, S., Mellon, P. J., Canalese, J., and Williams, R., Lancet1 (1982) 681.Google Scholar
  16. 16.
    Canalese, J., Gimson, A. E. S., Davis, C., Mellon, P. J., Davis, M., and Williams, R., Gut23 (1982) 625.Google Scholar
  17. 17.
    Thölen, H., and Mordhorst, R., Int. J. clin. Pharmac.10 (1974) 101.Google Scholar
  18. 18.
    Thölen, H., and Mordhorst, R., Experientia32 (1976) 830.Google Scholar
  19. 19.
    Angielski, S., Madrala, A., Pawlowska, D., Redlak, M., and Szczepanska-Konkel, M., Clin. Res.32 (1984) 429A.Google Scholar
  20. 20.
    Holloway, C. J., Brunner, G., Schmidt, E., and Schmidt, F. W., Art. Org.3 (1979) 15.Google Scholar
  21. 21.
    Foster, D., Ahmed, K., and Zieve, L., Ann. N.Y. Acad. Sci.242 (1974) 573.Google Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • H. Thölen
    • 1
  • W. Zimmerli
    • 1
  • Z. Rajacic
    • 1
  1. 1.Dept Innere Medizin and Dept ForschungKantonsspitalBasel(Switzerland)

Personalised recommendations