Summary
Male Fischer F-344 rats were given ethanol in the drinking water and/or by single oral administration. Following this, the animals received p.o. 100 ng/kg of the hepatocarcinogen [3H]aflatoxin B1 (AFB1). 24 h later, the level of DNA-bound AFB1 was determined in the liver and was found not to be affected by any type of ethanol pretreatment. A cocarcinogenic effect of ethanol in the liver is therefore unlikely to be due to an effect on the metabolic activation and inactivation processes governing the formation of DNA-binding AFB1 metabolites.
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References
Doll, R., and Peto, R., J. natn. Cancer Inst.66 (1981) 1191.
Obe, G., and Ristow, H., Mutation Res.65 (1979) 229.
Schottenfeld, D., Cancer43 (1979) 1962.
Lieber, C.S., Seitz, H.K., Garro, A.J., and Worner, T.M., Cancer Res.39 (1979) 2863.
McCoy, G.D., and Wynder, E.L., Cancer Res.39 (1979) 2844.
Swann, P., Presented at the 2nd int. Meeting on Xenobiotics and Biotransformation, 12–15 October, 1983, Alghero, Italy. Proc. Toxic. Path.12 (1984) in press.
Kouros, M., Mönch, W., Reiffer, F.J., and Dehnen, W., Carcinogenesis4 (1983) 1081.
McCoy, G.D., Hecht, S.S., Katayama, S., and Wynder, E.L., Cancer Res.41 (1981) 2849.
Pour, P.M., Reber, H.A., and Stepan, K., J. natn. Cancer Inst.71 (1983) 1085.
Griciute, L., Castegnaro, M., and Bereziat, J.-C., Cancer Lett.13 (1981) 345.
IARC Working Group, Cancer Res.40 (1980) 1.
Lutz, W.K., Mutation Res.65 (1979) 289.
Preston, R.S., Hayes, J.R., and Campbell, T.C., Life Sci.19 (1976) 1191.
Garner, R.C., Biochem. Pharmac.24 (1975) 1553.
Swenson, D.H., Lin, J.-K., Miller, E.C., and Miller, J.A., Cancer Res.37 (1977) 172.
Lutz, W.K., Jaggi, W., Lüthy, J., Sagelsdorff, P., and Schlatter, C., Chem.-biol. Interact.32 (1980) 249.
Peers, F.G., Gilman, G.A., and Linsell, C.A., Int. J. Cancer17 (1976) 167.
Sagelsdorff, P., Lutz, W.K., and Schlatter, C., Carcinogenesis4 (1983) 1267.
Huber, K.W., and Lutz, W.K., Carcinogenesis5 (1984) 403.
Croy, R.G., and Wogan, G.N., Cancer Res.41 (1981) 197.
Campbell, T.C., and Hayes, J.R., Toxic. appl. Pharmac.35 (1976) 199.
Sato, A., Nakajima, T., and Koyama, Y., Toxic. appl. Pharmac.60 (1981) 8.
Glinsukon, T., Taycharpipranai, S., and Toskulkao, C., Experientia34 (1978) 869.
Belinsky, S.A., Bedell, M.A., and Swenberg, J.A., Carcinogenesis3 (1982) 1293.
Schwarz, M., Wiesbeck, G., Hummel, J., and Kunz, W., Carcinogenesis3 (1982) 1071.
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Acknowledgment. We thank the European Science Foundation for the Toxicology Research Fellowship awarded to M.M.
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Marinovich, M., Lutz, W.K. Covalent binding of aflatoxin B1 to liver DNA in rats pretreated with ethanol. Experientia 41, 1338–1340 (1985). https://doi.org/10.1007/BF01952084
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DOI: https://doi.org/10.1007/BF01952084