Summary
The induction of unresponsiveness to mycobacterial adjuvant took a longer time in male DA rats than in female rats. A shift in the induction time of unresponsiveness in males toward the female type was brought about by castration, but could be reverted to the male type by the application of testosterone. The transfer study revealed that cells capable of preventing arthritis required a longer incubation time for their development in males than in females. This suggests that testosterone inhibits the development of suppressor cells in adjuvant arthritis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Glenn, E.M., and Gray, J., Am. J. vet. Res.26 (1965) 1180.
Ryzewska, A., Rheumatologia7 (1969) 195.
Eugui, E.M., and Houssay, R.H., Immunology28 (1975) 703.
Tsukano, M., Nawa, Y., and Kotani, M., Clin. exp. Immun.53 (1983) 60.
Griffiths, M.M., Eichwald, E.J., Martin, J.H., Smith, C.B., and DeWitt, C.W., Arthritis Rheum.24 (1981) 781.
Bottisto, J.R., Smith, R.N., Beckman, K., Sternlicht, M., and Wells, W.L., Arthritis Rheum.25 (1982) 1194.
Roubinian, J.R., Tatal, N., Greenspan, J.S., Goodman, J.R., and Sitteri, P.K., J. exp. Med.147 (1978) 1568.
Steinberg, A.D., Roths, J.B., Murphy, E.D., Steinberg, R.T., and Raveche, E.S., J. Immun.125 (1980) 871.
Author information
Authors and Affiliations
Additional information
Acknowledgments. We are grateful to The Naito Foundation Research Grant for 1983.
Rights and permissions
About this article
Cite this article
Tsukano, M., Kotani, M., Matsuno, K. et al. Effect of testosterone on the kinetics of the development of suppressor cells in adjuvant arthritis. Experientia 41, 1337–1338 (1985). https://doi.org/10.1007/BF01952083
Issue Date:
DOI: https://doi.org/10.1007/BF01952083