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Hemodynamic studies in a parabiotic model of portal hypertension

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Summary

Splanchnic and systemic hemodynamic studies were performed in a rat model of parabiosis and portal hypertension. A portal hypertensive and a normal rat were surgically united side to side. A hyperdynamic circulation, characterized by increased cardiac index (413±26 vs 318±23 ml·min−1·kg−1; p<0.05) and portal venous inflow (9.61±1.29 vs 6.33±0.36 ml·min−1·100 g b.wt−1; p<0.05), was found in all the portal hypertensive rats but not in the normal parabiotic partners. These results do not support the existence of a transferable humoral factor mediating the hyperdynamic circulatory state of chronic portal hypertension.

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Authors and Affiliations

  1. Hepatic Hemodynamic Laboratory, Veterans Administration Medical Center, 06516, West Haven, Connecticut, USA

    E. Sikuler & R. J. Groszmann

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    E. Sikuler & R. J. Groszmann

Authors
  1. E. Sikuler
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  2. R. J. Groszmann
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Acknowledgment. The authors express their appreciation to Martha Shea for technical assistance.

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Sikuler, E., Groszmann, R.J. Hemodynamic studies in a parabiotic model of portal hypertension. Experientia 41, 1323–1324 (1985). https://doi.org/10.1007/BF01952076

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  • DOI: https://doi.org/10.1007/BF01952076

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