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The effects of beta-endorphin on arginine-8-vasopressin and oxytocin levels in rat brain areas

Experientia volume 45, pages 472–474 (1989)Cite this article

Summary

Measurements were made of the effects of intracerebroventricular treatment with beta-endorphin (BE; 100 ng) on the arginine-8-vasopressin (AVP) and oxytocin contents of rat hypothalamic and limbic brain areas (hippocampus, amygdala and septum). The hormone concentrations were determined by radioimmunoassay. The administration of BE resulted in a significant reduction of the AVP level in the amygdala in a naloxone-reversible manner. Naloxone (Nal) administered subcutaneously significantly increased the AVP content in the septum. The results revealed that BE and Nal had regionally specific effects on the activity of the vasopressinergic system but not on that of the oxytocinergic system in the brain.

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Affiliations

  1. Endocrine Unit and Research Laboratory, First Department of Medicine, Albert Szent-Györgyi Medical University, POB 469, H-6701, Szeged, (Hungary)

    M. Vecsernyés, F. Laczi & T. Janáky

  2. Central Laboratory, Markusovszky Teaching Hospital, Szombathely, (Hungary)

    G. L. Kovács

  3. Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, (Hungary)

    G. Szabó & G. Telegdy

  4. Department of Comparative Physiology, Attila József University of Sciences, Szeged, (Hungary)

    F. A. László

Authors
  1. M. Vecsernyés
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  2. F. Laczi
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  3. G. L. Kovács
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  4. G. Szabó
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  5. T. Janáky
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  6. G. Telegdy
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  7. F. A. László
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Vecsernyés, M., Laczi, F., Kovács, G.L. et al. The effects of beta-endorphin on arginine-8-vasopressin and oxytocin levels in rat brain areas. Experientia 45, 472–474 (1989). https://doi.org/10.1007/BF01952034

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  • DOI: https://doi.org/10.1007/BF01952034

Key words

  • Beta-endorphin
  • vasopressin
  • oxytocin
  • brain regions