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Purification of α-ketoaldehyde dehydrogenase from the human liver and its possible significance in the control of glycation

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Summary

Alfa-ketoaldehyde dehydrogenase, which was extracted and purified from human livers, may act on carbonyl compounds, such as 3-deoxyglucosone, and be involved in the control of glycation (Maillard reaction) in the body.

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Abbreviations

3-DG:

3-deoxyglucosome

SDS:

sodium dodecyl sulfate

DEAE:

diethyl-aminoethanol

AGE:

advanced glycosylation end-product

p-CMB:

para-chloromercuribenzoate

FFI:

2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole

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Authors and Affiliations

  1. The Second Department of Internal Medicine, Kobe University School of Medicine, 5-1, 7-chome, Kusunoki-cho, Chuo-ku, 650, Kobe, Japan

    M. Oimomi, F. Hata, N. Igaki, T. Nakamichi & S. Baba

  2. Department of Agricultural Chemistry, The University of Tokyo, 1-1, 1-chome, Yayoi, 113, Bunkyo-ku, Tokyo, Japan

    H. Kato

Authors
  1. M. Oimomi
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  2. F. Hata
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  3. N. Igaki
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  4. T. Nakamichi
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  5. S. Baba
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  6. H. Kato
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Oimomi, M., Hata, F., Igaki, N. et al. Purification of α-ketoaldehyde dehydrogenase from the human liver and its possible significance in the control of glycation. Experientia 45, 463–466 (1989). https://doi.org/10.1007/BF01952031

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  • DOI: https://doi.org/10.1007/BF01952031

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