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Metabolic implications in the elevation of serum activity of intestinal alkaline phosphatase in chronic renal failure

Experientia volume 40, pages 896–898 (1984)Cite this article

Summary

The activity of intestinal isoenzyme of serum alkaline phosphatase was evaluated in 21 non-dialyzed patients with advanced renal failure and in 52 patients on regular hemodialysis. In patients without hepatopathy, a significant inverse correlation was found between the enzyme activity and serum calcium levels. Hepatopathy was the most significant variable influencing the enzyme activity in patients on dialysis. Secondary hyperparathyroidism and a decreased rate in enzyme elimination should be assessed for the above-normal activities of intestinal ALP in serum in chronic renal failure.

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Affiliations

  1. 3rd Department of Internal Medicine, and 2nd Department of Internal Medicine, Charles University Faculty of Medicine, U nemocnice 1, CS-12800, Praha, (Czechoslovakia)

    J. Štěpán, T. Havránek, E. Jelínková, M. Straková, J. Škrha & V. Pacovský

  2. Centre of Biomathematics, Czechoslovak Academy of Sciences, Praha, (Czechoslovakia)

    J. Štěpán, T. Havránek, E. Jelínková, M. Straková, J. Škrha & V. Pacovský

Authors
  1. J. Štěpán
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  2. T. Havránek
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  3. E. Jelínková
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  4. M. Straková
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  5. J. Škrha
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  6. V. Pacovský
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Štěpán, J., Havránek, T., Jelínková, E. et al. Metabolic implications in the elevation of serum activity of intestinal alkaline phosphatase in chronic renal failure. Experientia 40, 896–898 (1984). https://doi.org/10.1007/BF01952015

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  • DOI: https://doi.org/10.1007/BF01952015

Keywords

  • Enzyme
  • Alkaline Phosphatase
  • Chronic Renal Failure
  • Hyperparathyroidism
  • Serum Calcium