Summary
Chronic active hepatitis was selectively induced in mice by the feeding of a diet containing 3-hydroxy-4-pyrone (0.5% by weight) for periods of 6 weeks and longer. This model should be of particular value in elucidating the pathogenesis of drug-induced forms of chronic active hepatitis. Maltol (3-hydroxy-2-methyl-4-pyrone) did not produce any liver lesion.
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Acknowledgment. This research was supported in part by a grant from the Sir A.E. Rowden White Bequest to the Department of Pathology, University of Melbourne.
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Bhathal, P.S., Ho, S.L., Hegarty, M.P. et al. Chronic active hepatitis in mice induced by 3-hydroxy-4-pyrone. Experientia 40, 894–896 (1984). https://doi.org/10.1007/BF01952014
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DOI: https://doi.org/10.1007/BF01952014