Experientia

, Volume 40, Issue 8, pp 879–881 | Cite as

Teratogenic effects of methylnitrosourea on pregnant mice before implantation

  • I. K. Takeuchi
Short Communications

Summary

Methylnitrosourea at a dose of 10 mg/kg is teratogenic when applied to pregnant mice on gestational days 2.5, 3.5 or 4.5, but has no such effects on gestational days 0.5 and 1.5.

Keywords

Teratogenic Effect Pregnant Mouse Methylnitrosourea 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Miller, R. K., Am. J. ind. Med.4 (1983) 205.Google Scholar
  2. 2.
    Tuchmann-Duplessis, H., Am. J. ind. Med.4 (1983) 245.Google Scholar
  3. 3.
    Rugh, R., and Grupp, E., J. Neuropath. exp. Neurol.18 (1959) 468.Google Scholar
  4. 4.
    Rugh, R., Am. J. Roentg.87 (1962) 559.Google Scholar
  5. 5.
    Gottschewski, G. H. M., Nature201 (1964) 1232.Google Scholar
  6. 6.
    Roux, Ch., Archs fr. Pédiat.21 (1964) 451.Google Scholar
  7. 7.
    Persaud, T. V. N., Naturwissenschaften56 (1969) 37.Google Scholar
  8. 8.
    Bell, P. S., and Glass, R. H., Fert. Steril.26 (1975) 449.Google Scholar
  9. 9.
    Wendler, D., Gabler, W., and Schmidt, W., Anat. Anz.139 (1976).115.Google Scholar
  10. 10.
    Goldman, A. S., Endocrinology84 (1969) 1206.Google Scholar
  11. 11.
    Napalkov, N. P., and Alexandrov, V. A., Z. Krebsforsch.71 (1968) 32.Google Scholar
  12. 12.
    Tamaki, N., Taomoto, K., Fujiwara, K., Oi, Y., and Matsumoto, S., Neurol. med. chir., Tokyo17 (1977) 435.Google Scholar
  13. 13.
    Haseman, J. K., and Hogan, M. D., Teratology12 (1975) 165.Google Scholar
  14. 14.
    Spielman, H., and Eibs, H.-G., Arzneimittel-Forsch.28 (1978) 1733.Google Scholar
  15. 15.
    Iannaccone, P. M., Tsao, T. Y., and Stols, L., Cancer Res.42 (1982) 864.Google Scholar
  16. 16.
    Gebhardt, D. O. E., Teratology3 (1970) 273.Google Scholar
  17. 17.
    Magnuson, T., and Epstein, C. J., Biol. Rev.56 (1981) 369.Google Scholar
  18. 18.
    Johnson, M. H., Biol. Rev.56 (1981) 463.Google Scholar

Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • I. K. Takeuchi
    • 1
  1. 1.Department of EmbryologyInstitute for Developmental Research, Aichi Prefectural ColonyKasugai, Aichi(Japan)

Personalised recommendations