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3H) spiroperidol binding decreases in brains of rats infected with Venezuelan equine encephalomyelitis virus1

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Summary

After i.p. inoculation with the Guajira strain of Venezuelan equine encephalomyelitis virus a significant decrease in the density of (3H) spiroperidol binding sites in the striatum, midbrain and frontal cortex was observed. No changes in the affinity of the receptors could be demonstrated. This finding is compatible with neuronal degeneration caused by the viral infection.

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Authors and Affiliations

  1. Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad del Zulia and Inbiomed-Fundacite, Apartado 1151, Maracaibo, Venezuela

    E. Bonilla, M. Salazar, J. Estevez, H. Hernández & P. Rangel

Authors
  1. E. Bonilla
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  2. M. Salazar
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  3. J. Estevez
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  4. H. Hernández
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  5. P. Rangel
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Additional information

Acknowledgments. This work was partially supported by Condes-Luz and Fundacite-Zulia. Butaclamol isomers were a gift of Ayerst Laboratories, Montreal, Canada.

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Bonilla, E., Salazar, M., Estevez, J. et al. 3H) spiroperidol binding decreases in brains of rats infected with Venezuelan equine encephalomyelitis virus1. Experientia 40, 868–869 (1984). https://doi.org/10.1007/BF01952000

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  • DOI: https://doi.org/10.1007/BF01952000

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