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Antagonism by haloperidol of the suppression of exploratory locomotor activity induced by the local application of(−)3-(3-hydroxyphenyl)-N-n-propylpiperidine into the nucleus accumbens of the rat

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Summary

The injection of (−)3-PPP into the nucleus accumbens, 10 μg/side, produced a suppression of exploratory locomotor activity without affecting treadmill locomotion. Furthermore, the suppression of exploratory locomotor activity produced by (−)3-PPP was antagonized by the administration of haloperidol, 25–50 μg/kg i.p.

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Literatur

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Authors and Affiliations

  1. Research and Development Laboratories, Pharmacology, Astra Läkemedel AB, S-15185, Södertälje, Sweden

    S. Ahlenius, L. Svensson, V. Hillegaart & O. Thorberg

  2. Department of Psycology, University of Göteborg, Box 14158, S-400 20, Göteborg, Sweden

    S. Ahlenius, L. Svensson, V. Hillegaart & O. Thorberg

Authors
  1. S. Ahlenius
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  2. L. Svensson
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  3. V. Hillegaart
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  4. O. Thorberg
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Additional information

Acknowledgments. The figures were prepared by M. Kröning at the Department of Psychology, University of Göteborg. This work was supported by Torsten and Ragnar Söderberg's Foundation, Magn. Bergvall Foundation and Åke Wiberg Foundation.

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Ahlenius, S., Svensson, L., Hillegaart, V. et al. Antagonism by haloperidol of the suppression of exploratory locomotor activity induced by the local application of(−)3-(3-hydroxyphenyl)-N-n-propylpiperidine into the nucleus accumbens of the rat. Experientia 40, 858–859 (1984). https://doi.org/10.1007/BF01951994

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  • DOI: https://doi.org/10.1007/BF01951994

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