Summary
Several N-1-alkyl-, 3-, and 4-carbamidopyridinium halides were synthesized and determined to be inhibitors of mitochondrial oxidative phosphorylation. L-Glutamate respiration was most depressed by N-1-dodecylpyridinium bromide whereas succinate respiration was most depressed by N-1-dodecylisonicotinamide bromide. Combination of inhibitors with mitochondrial sites may involve lipophilic interactions as modified by steric restrictions.
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Rogers, K.S., Higgins, E.S. Differential inhibition of mitochondrial respiratory control by N-1-substituted, 3-, 4-substituted pyridinium halides. Experientia 40, 848–849 (1984). https://doi.org/10.1007/BF01951988
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DOI: https://doi.org/10.1007/BF01951988