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Peptide interactions with taste receptors: Overlap in taste receptor specificity

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Summary

Two hitherto unrelated areas of taste appear to provide an important insight into a class of taste receptor sites. A region of the sweet protein monellin is similar to a savory tasting beef octapeptide, and this peptide region could represent an overlap in the specificity of binding to a common peptide taste receptor site. Such an overlap in binding specificity explains the low but significant level of sweetness observed with savory tasting stimuli.

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Authors and Affiliations

  1. Veterans Administration Medical Center and Monell Chemical Senses Center and University of Pennsylvania, 19104, Philadelphia, Pennsylvania, USA

    R. H. Cagan

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  1. R. H. Cagan
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Additional information

The work from this laboratory was supported by NIH Research Grant No. NS-15740 from NINCDS and by the Veterans Administration.

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Cagan, R.H. Peptide interactions with taste receptors: Overlap in taste receptor specificity. Experientia 40, 843–844 (1984). https://doi.org/10.1007/BF01951985

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  • DOI: https://doi.org/10.1007/BF01951985

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