, Volume 40, Issue 8, pp 815–816 | Cite as

Release of labile cyclo-oxygenase products of arachidonic acid from kidney by endotoxin

  • K. Özsan
  • V. Içöz
  • R. K. Türker
Short Communications


The possible release of prostaglandin (PG)-like substances was studied in isolated perfused kidneys from intact and from intrarenal endotoxin (Lipopolysaccharide-LPS)-injected rabbits, using the venous outflow superflow superfuse assay organ technique. Injection of LPS into the renal artery of an LPS-pretreated kidney caused a release of thromboxane A2 (TXA2) and prostacyclin (PGI2)-like materials into the venous effluent as verified by the responses of the specific assay organs. No detectable release of these substances was found in the venous outflow of LPS-injected intact kidney. The possible role of labile cyclo-oxygenase products of arachidonic acid in the Shwartzman reaction is discussed.


Prostaglandin Arachidonic Acid Renal Artery Thromboxane Prostacyclin 
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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • K. Özsan
    • 1
  • V. Içöz
    • 1
  • R. K. Türker
    • 1
  1. 1.Departments of Microbiology, Thorasic Surgery and Pharmacology, Faculty of MedicineUniversity of AnkaraAnkara(Turkey)

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