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Experientia

, Volume 40, Issue 8, pp 815–816 | Cite as

Release of labile cyclo-oxygenase products of arachidonic acid from kidney by endotoxin

  • K. Özsan
  • V. Içöz
  • R. K. Türker
Short Communications

Summary

The possible release of prostaglandin (PG)-like substances was studied in isolated perfused kidneys from intact and from intrarenal endotoxin (Lipopolysaccharide-LPS)-injected rabbits, using the venous outflow superflow superfuse assay organ technique. Injection of LPS into the renal artery of an LPS-pretreated kidney caused a release of thromboxane A2 (TXA2) and prostacyclin (PGI2)-like materials into the venous effluent as verified by the responses of the specific assay organs. No detectable release of these substances was found in the venous outflow of LPS-injected intact kidney. The possible role of labile cyclo-oxygenase products of arachidonic acid in the Shwartzman reaction is discussed.

Keywords

Prostaglandin Arachidonic Acid Renal Artery Thromboxane Prostacyclin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • K. Özsan
    • 1
  • V. Içöz
    • 1
  • R. K. Türker
    • 1
  1. 1.Departments of Microbiology, Thorasic Surgery and Pharmacology, Faculty of MedicineUniversity of AnkaraAnkara(Turkey)

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