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Cholesterol content and cholesterol esterifying activity of various organs in guinea pigs

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Summary

In various organs of the guinea pig, the total cholesterol content of an organ was significantly correlated with the percentage of esterified cholesterol present in this organ. Cholesterol esterifying capacity was shown in most organs, with highest activities in the adrenals, the spleen and the liver. The significant correlation found between the cholesteryl ester content of an organ and its acyl cholesterol acyltransferase activity suggests a possible role of this enzyme in determining the level of the total and esterified cholesterol in a tissue.

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Authors and Affiliations

  1. Laboratoire de Pharmacothérapie, Université Catholique de Louvain, 53, avenue E.-Mounier, B-1200, Bruxelles, Belgium

    F. R. Heller

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  1. F. R. Heller
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Additional information

This work was supported by a grant ‘Crédit aux Chercheurs’ du Fonds National de la Recherche Scientifique of Belgium.

Acknowledgments. I am indebted to Prof. C. Harvengt for his stimulating interest and helpful suggestions. I wish to thank Y. van Nieuwenhuyze and J. Costermans for their valuable laboratory assistance and Dr H. Baudon for pathological studies.

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Heller, F.R. Cholesterol content and cholesterol esterifying activity of various organs in guinea pigs. Experientia 40, 1373–1375 (1984). https://doi.org/10.1007/BF01951896

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