Summary
Continuous administration of leukotriene C4 (LTC4, 10−10 M) to superfused rat anterior pituitary cells increased LH release for 40 min only, whereas in a parallel experiment gonadotropin-releasing hormone (GnRH, 10−9 M) evoked a continuous increase in hormone secretion. In contrast to GnRH, LTC4 did not desensitize rat anterior pituitary cells. The secretory action resulting from the administration of LTC4 (10−10 M) was abolished for 40 min after previous stimulation. The results documented the dual action of LTC4 on LH exocytosis.
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Przylipiak, A., Kiesel, L., Przylipiak, M. et al. Differences in luteinizing hormone release stimulated in rat anterior pituitary cells by leukotriene C4 and by gonadotropin-releasing hormone in vitro. Experientia 46, 298–300 (1990). https://doi.org/10.1007/BF01951771
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DOI: https://doi.org/10.1007/BF01951771