, Volume 46, Issue 3, pp 290–292 | Cite as

Stress-induced increase in noradrenaline release in the rat hypothalamus assessed by intracranial microdialysis

  • H. Yokoo
  • M. Tanaka
  • T. Tanaka
  • A. Tsuda
Research Articles


The hypothalamic microdialysis of conscious rats was used to investigate the effects of immobilization stress (20 min) on extracellular noradrenaline(NA) levels. The stress significantly increased NA levels relative to basal efflux by 106% and this elevation continued for 40 min after release from stress.

Key words

In vivo microdialysis stress noradrenaline release hypothalamus high performance liquid chromatography rat 


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  1. 1.
    Stone, E. A., in: Catecholamines and Behavior, vol. 2, p. 31. Ed. A. J. Friedhoff, Plenum Press, New York 1975.Google Scholar
  2. 2.
    Bliss, E. L. and Zwanziger, J., J. Psychiat. Res.4 (1966) 189.Google Scholar
  3. 3.
    Ceasar, P. M., Hague, P., Sharman, D. F., and Werdinius, B., Br. J. Pharmac.51 (1974) 187.Google Scholar
  4. 4.
    Tanaka, M., Kohno, Y., Nakagawa, R., Ida, Y., Takeda, S., and Nagasaki, N., Pharmac. Biochem. Behav.16 (1982) 315.Google Scholar
  5. 5.
    Tanaka, M., Kohno, Y., Nakagawa, R., Ida, Y., Takeda, S., Nagasaki, N., and Noda, Y., Pharmac. Biochem. Behav.19 (1983) 543.Google Scholar
  6. 6.
    Ungerstedt, U., in: Measurement of Neurotransmitter Release In Vivo, p. 81. Ed. C. A. Marsden. John Wiley and Sons Ltd, Chichester 1984.Google Scholar
  7. 7.
    Badoer, E., Würth, H., Türck, D., Qadri, F., Itoi, K., Dominiak, P., and Unger, Th., Naunyn-Schmiedeberg's Arch. Pharmac.339 (1989). 54.Google Scholar
  8. 8.
    Paxinos, G., and Watoson, C., The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney 1982.Google Scholar
  9. 9.
    L'Heureux, R., Dennis, T., Curet, O., and Scatton, B., J. Neurochem.46 (1986) 1794.PubMedGoogle Scholar
  10. 10.
    Schanberg, S. M., Schidkraut, J. J., Breese G. R., and Kopin, I. J., Biochem. Pharmac.17 (1968) 247.Google Scholar
  11. 11.
    Sugden, R. F., and Eccleston, D., J. Neurochem.18 (1971) 2461.PubMedGoogle Scholar
  12. 12.
    Tsuda, A., Tanaka, M., Ida, Y., Shirao, I., Gondoh, Y., Oguchi, M., and Yoshida, M., Brain Res.474 (1988) 174.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • H. Yokoo
    • 1
  • M. Tanaka
    • 1
  • T. Tanaka
    • 1
  • A. Tsuda
    • 1
  1. 1.Department of PharmacologyKurume University School of MedicineKurume(Japan)

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