, Volume 46, Issue 3, pp 283–285 | Cite as

Hypothalamic histamine modulates adaptive behavior of rats at high environmental temperature

  • K. Fujimoto
  • T. Sakata
  • K. Ookuma
  • M. Kurokawa
  • A. Yamatodani
  • H. Wada
Research Articles


Histamine content in the rat hypothalamus was lower at 4°C and higher at 31°C compared to that at 21°C. Pretreatment with α-fluoromethylhistidine, a ‘suicide’ inhibitor of histidine decarboxylase, attenuated both the increased level of hypothalamic histamine and rat adaptive behavior at 31°C. Increase of histamine content in the hypothalamus appears to be an important factor contributing to rat adaptive behavior to high environmental temperature.

Key words

Histamine hypothalamus environmental temperature adaptive behavior 


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Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • K. Fujimoto
    • 1
  • T. Sakata
    • 1
  • K. Ookuma
    • 1
  • M. Kurokawa
    • 1
  • A. Yamatodani
    • 2
  • H. Wada
    • 2
  1. 1.Department of Internal Medicine I, Faculty of MedicineKyushu UniversityFukuokaJapan
  2. 2.Department of Pharmacology II, Faculty of MedicineOsaka UniversityOsakaJapan

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