Advertisement

Experientia

, Volume 46, Issue 3, pp 274–276 | Cite as

Widespread occurrence of 2-acetylthiazole-4-carboxylic acid in biological material

  • R. H. White
Research Articles

Summary

2-Acetylthiazole-4-carboxylic acid was shown to be widely distributed in all organisms tested, which included members of the eukaryotes, archaebacteria, and eubacteria. This thiazole, which was identified and quantitated as the methyl ester methoxyamine derivative, was found in these organisms at levels of from 27 to 1100 nmol/g dry weight (d.wt) of tissue. On the basis of its widespread occurrence, the levels at which it occurs in these organisms, and its chemical structure, which contains a reactive carbonyl group, it is proposed that this compound is a previously undescribed coenzyme.

Key words

2-Acetylthiazole-4-carboxylic acid coenzymes distribution 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    White, R. H., Archs Biochem. Biophys.270 (1989) 691.Google Scholar
  2. 2.
    Katritzky, A. R., and Rees, C. W., Comprehensive Heterocyclic Chemistry, vol. 6, part 4B, p. 256. Pergamon Press, Oxford 1984.Google Scholar
  3. 3.
    Metzger, J. V., and Vincent, E.-J., in: Thiazole and its Derivatives, part 1, p. 92. Ed. J. V. Metzger. John Wiley & Sons, New York 1968.Google Scholar
  4. 4.
    Pal, R., and Spiteller, G., Xenobiotica12 (1982) 813.PubMedGoogle Scholar
  5. 5.
    Brookes, P., Clark, R. J., Fuller, A. T., Mijovic, M. P. V., and Walker, J., J. chem. Soc.1960 916.Google Scholar
  6. 6.
    Takita, T., Muraoka, Y., Fujii, A., Itoh, A., Maeda, K., and Umezawa, H., J. Antibiotics25 (1972) 197.Google Scholar
  7. 7.
    Konda, Y., Suzuki, Y., Omura, S., and Onda, M., Chem. Pharm. Bull.24 (1976) 92.PubMedGoogle Scholar
  8. 8.
    Leigh, J. A., Appl. envir. Microbiol.45 (1983) 800.Google Scholar
  9. 9.
    Noll, K. M., and Barber, T. S., J. Bact.170 (1988) 4315.PubMedGoogle Scholar
  10. 10.
    White, R. H., Biochemistry24 (1985) 6487.Google Scholar
  11. 11.
    Smith, H. A., and Gorin, G., J. org. Chem.26 (1961) 820.Google Scholar
  12. 12.
    Barton, M. A., Kenner, G. W., and Sheppard, R. C., J. chem. Soc. (C)1966, 1061.Google Scholar
  13. 13.
    Crews, P., Kakou, Y., and Quinoa, E., J. Am. chem. Soc.110 (1988) 4365.Google Scholar
  14. 14.
    Pettit, G. R., Kamano, Y., Brown, P., Gust, D., Inoue, M., and Hearld, C. L., J. Am. chem. Soc.104 (1982) 905.Google Scholar
  15. 15.
    Recsei, P. A., and Snell, E. E., A. Rev. Biochem.53 (1984) 357.Google Scholar
  16. 16.
    White, R. H., Biochemistry17 (1978) 3833.PubMedGoogle Scholar
  17. 17.
    White, R. H., Biochemistry26 (1987) 3163.Google Scholar

Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • R. H. White
    • 1
  1. 1.Department of Biochemistry and NutritionVirginia Polytechnic Institute and State UniversityBlacksburgUSA

Personalised recommendations