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Possible involvement of calmodulin in apical constriction of neuroepithelial cells and elevation of neural folds in the chick

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Summary

Chlorpromazine and trifluoperazine HCl, antipsychotic drugs known to bind to calmodulin, reversibly inhibited elevation of neural folds by interfering with the contractile activity of apical microfilament bundles in developing chick neuroepithelial cells.

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Authors and Affiliations

  1. Department of Biology, Rutgers University, 08102, Camden, New Jersey, USA

    H. Lee & R. G. Nagele

  2. Department of Pediatrics, UMDNJ-School of Osteopathic Medicine, 08103, Camden, New Jersey, USA

    H. Lee & R. G. Nagele

Authors
  1. H. Lee
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  2. R. G. Nagele
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Additional information

We wish to thank C. Hess for her technical assistance. This study was supported in part by grants from the Busch Fund (Rutgers University), UMDNJ Foundation and Kapnek Fund.

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Lee, H., Nagele, R.G. Possible involvement of calmodulin in apical constriction of neuroepithelial cells and elevation of neural folds in the chick. Experientia 41, 1186–1188 (1985). https://doi.org/10.1007/BF01951721

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  • DOI: https://doi.org/10.1007/BF01951721

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