Summary
The chemical composition of liver plasma membrane was studied in Wistar rats aged between 3 and 24 months. Results obtained indicate a significant age-dependent positive correlation of both the protein:phospholipid and cholesterol:phospholipid ratios, whereas the protein:cholesterol ratio seems to remain unaffected. Phospholipid analysis of liver plasma membrane reveals that only the phosphatidylcholine content has a significant negative correlation with age; all other phospholipid species remain basically unchanged.
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Supported by a grant of the Italian National Research Council, Project ‘Preventive and Rehabilitative Medicine’, Subproject ‘Mechanisms of Aging’.
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Spinedi, A., Rufini, S. & Luly, P. Age-dependent changes of rat liver plasma membrane composition. Experientia 41, 1141–1143 (1985). https://doi.org/10.1007/BF01951698
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DOI: https://doi.org/10.1007/BF01951698