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Effects of exchange transfusion with perfluorochemical emulsions on hepatic oxygen supply and blood flow in the rat

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Summary

Exchange-transfusion to hematocrit 20 with isotonic perfluorochemical (PFC) emulsions containing 3% hydroxyethylstarch (HES) in rats breathing 100% oxygen produced significant reductions of hepatic PO2 and blood flow in comparison to rats hemodiluted with isotonic 3% or 6% HES solution. The results indicate that PFC and/or emulsifiers were associated with adverse effects on liver blood supply.

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References

  1. Clark, L. C. Jr, in: Pathophysiology of shock, anoxia and ischemia, p. 507. Eds R. Cowley and B. Trump, Williams and Wilkins, Baltimore 1982.

    Google Scholar 

  2. Mitsuno, T., Ohyanagi, H., and Naito, R., Ann. Surg.195 (1982) 60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Tremper, K. K., Friedman, A. E., Levine, E. M., Lapin, R., and Carmarillo, D., N. Engl. J. Med.307 (1982) 277.

    Article  CAS  PubMed  Google Scholar 

  4. Messmer, K., Int. Anaesth. Clin.21 (1983) 137.

    Article  CAS  Google Scholar 

  5. Endrich, B., Newman, M. M., Greenburg, A. G., and Intaglietta, M., J. Surg. Res.29 (1980) 516.

    Article  CAS  PubMed  Google Scholar 

  6. Vercellotti, G. M., Hammerschmidt, D. E., Craddock, P. R., and Jacob, H. S., Blood59 (1982) 1299.

    Article  CAS  PubMed  Google Scholar 

  7. Kessler, M., and Grunewald, W., Prog. Resp. Res.3 (1969) 147.

    Article  Google Scholar 

  8. Lubbers, D. W., Prog. Resp. Res.3 (1969) 112.

    Article  Google Scholar 

  9. Paumgartner, G., Schweiz. med. Wschr., suppl.105 (1975) 1.

    Google Scholar 

  10. Zheng, X. X., and Ohshima, N., Microvasc. Res.26 (1983) 371.

    Google Scholar 

  11. Coleman, R. W., Chang, L. K., Mukherji, B., and Sloviter, H. A., J. Lab. clin. Med.95 (1980) 553.

    Google Scholar 

  12. Pohl, V., Güggi, M., Höper, J., and Kessler, M., Biblthca anat.20 (1981) 399.

    Google Scholar 

  13. Messmer, K., Surg. Clin. N. Am.55 (1975) 659.

    Article  CAS  PubMed  Google Scholar 

  14. Koo, A., Liang, I. V. S., and Cheng, K. K., Q. J. exp. Physiol.60 (1975) 261.

    Article  CAS  PubMed  Google Scholar 

  15. Rink, R. D., Fitch, K. A., and Giamarra, B., Fedn Proc.43 (1983) 340.

    Google Scholar 

  16. Kessler, M., Höper, J., and Pohl, V., in: Oxygen carrying colloidal blood substitutes, p. 99. Eds R. Frey, H. Beisbarth and K. Stosseck. Munich 1982.

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Authors and Affiliations

  1. Department of Anatomy, University of Louisville School of Medicine, Health Sciences Center, 40292, Louisville, Kentucky, USA

    W. B. Bizot & R. D. Rink

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  1. W. B. Bizot
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  2. R. D. Rink
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This work was supported by a grant from the Kentucky Affiliate of the American Heart Association.

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Bizot, W.B., Rink, R.D. Effects of exchange transfusion with perfluorochemical emulsions on hepatic oxygen supply and blood flow in the rat. Experientia 41, 1127–1129 (1985). https://doi.org/10.1007/BF01951691

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