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Evidence that superoxide radicals are involved in the hemolytic mechanism of phenylhydrazine

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  • Haematologica, Immunologica
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Summary

Phenylhydrazine produces in the red blood cell the same effect as the enzymic system xanthine oxidase-xanthine, a superoxide radical generator system. Both effects are inhibited by the enzyme superoxide dismutase.

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Author notes

  1. H. Ríos

    Present address: Facultad de Medicina-Sur, Departamento de Ciencias Médico Biológicas y Básicas, Universidad de Chile, Santiago, Chile

Authors and Affiliations

  1. Laboratorio de Bioquímica, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Casilla 15138, Santiago 11, Chile

    A. Valenzuela, H. Ríos & G. Neiman

Authors
  1. A. Valenzuela
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  2. H. Ríos
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  3. G. Neiman
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Additional information

This work was supported in part by grants Nos. 1045 and 3243 of Oficina Técnica de Desarrollo Científico y Creación Artística de la Universidad de Chile.

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Valenzuela, A., Ríos, H. & Neiman, G. Evidence that superoxide radicals are involved in the hemolytic mechanism of phenylhydrazine. Experientia 33, 962–963 (1977). https://doi.org/10.1007/BF01951306

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  • DOI: https://doi.org/10.1007/BF01951306

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