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Isethionate may not be an inert substitute for extracellular chloride in the central nervous system

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  • Physiologica
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Summary

Replacement of extracellular chloride with isethionate or methylsulphate causes an increased efflux of 1-[14C]-GABA from the in vivo superfused rat cuneate nucleus. This raises the question of the suitability of these anions as inert substitutes for chloride in studies on the ionic dependency of membrane phenomena in the central nervous system.

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Authors and Affiliations

  1. Department of Physiology, Marischal College, University of Aberdeen, Broad Street, AB9 1 AS, Aberdeen, Scotland

    N. Bernardi, J. A. Assumpção, N. Davidson & C. G. Dacke

Authors
  1. N. Bernardi
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  2. J. A. Assumpção
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  3. N. Davidson
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  4. C. G. Dacke
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Additional information

Supported in part by a grant from the Medical Endowment Funds of the University of Aberdeen.

N. B. supported by grants from CAPES and FAPESP, Brazil, J. A. A. supported by grants from CNPq and FAPESP, Brazil.

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Bernardi, N., Assumpção, J.A., Davidson, N. et al. Isethionate may not be an inert substitute for extracellular chloride in the central nervous system. Experientia 33, 914–915 (1977). https://doi.org/10.1007/BF01951278

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  • DOI: https://doi.org/10.1007/BF01951278

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