, Volume 45, Issue 11–12, pp 1129–1131 | Cite as

Suppression of mitogen- and antigen-induced lymphocyte proliferation by lanthanides

  • M. Yamage
  • C. H. Evans
Research Articles


Lanthanide ions (Ln3+) inhibited the proliferative response of human lymphocytes to various polyclonal mitogens and the ‘purified protein derivative’ (PPD) of the tuberculin antigen. Of the four Ln3+ ions tested lanthanum (La3+) was the strongest inhibitor; erbium (Er3+) and lutetium (Lu3+) were only weakly active, while samarium (Sm3+) had intermediate potency. At a concentration of 1 mM, La3+ almost completely inhibited the uptake of [3H]-thymidine by lymphocytes exposed to mitogenic agents. Trypan blue exclusion tests confirmed that the La3+ ions were not toxic. These findings may bear upon the reported anti-inflammatory properties of the lanthanides.

Key words

Lanthanide lymphocyte cell division inflammation 


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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • M. Yamage
    • 1
  • C. H. Evans
    • 2
  1. 1.Research Laboratory for Biomaterials, InselspitalUniversity of BernBernSwitzerland
  2. 2.Ferguson Laboratory for Orthopedic ResearchUniversity of Pittsburgh School of MedicinePittsburghUSA

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