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Suppression of mitogen- and antigen-induced lymphocyte proliferation by lanthanides

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Summary

Lanthanide ions (Ln3+) inhibited the proliferative response of human lymphocytes to various polyclonal mitogens and the ‘purified protein derivative’ (PPD) of the tuberculin antigen. Of the four Ln3+ ions tested lanthanum (La3+) was the strongest inhibitor; erbium (Er3+) and lutetium (Lu3+) were only weakly active, while samarium (Sm3+) had intermediate potency. At a concentration of 1 mM, La3+ almost completely inhibited the uptake of [3H]-thymidine by lymphocytes exposed to mitogenic agents. Trypan blue exclusion tests confirmed that the La3+ ions were not toxic. These findings may bear upon the reported anti-inflammatory properties of the lanthanides.

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Authors and Affiliations

  1. Research Laboratory for Biomaterials, Inselspital, University of Bern, CH-3010, Bern, Switzerland

    M. Yamage

  2. Ferguson Laboratory for Orthopedic Research, University of Pittsburgh School of Medicine, 15261, Pittsburgh, Pennsylvania, USA

    C. H. Evans

Authors
  1. M. Yamage
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  2. C. H. Evans
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Yamage, M., Evans, C.H. Suppression of mitogen- and antigen-induced lymphocyte proliferation by lanthanides. Experientia 45, 1129–1131 (1989). https://doi.org/10.1007/BF01950178

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