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Experientia

, Volume 45, Issue 11–12, pp 1099–1102 | Cite as

In vivo degradation of noradrenaline by MAO A in locus coeruleus of the rat

  • M. Blinc
  • M. Dernovšek
  • D. Sket
Research Articles

Summary

Depletion of noradrenaline in locus coeruleus neurons after reserpinization was prevented by clorgyline, a selective inhibitor of MAO A, but not by deprenyl, a selective inhibitor of MAO B. Only MAO A is therefore responsible for the degradation of homoneuronal noradrenaline in locus coeruleus nerve cells.

Key words

MAO A MAO B locus coeruleus rat noradrenaline histofluorescence reserpine deprenyl clorgyline 

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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • M. Blinc
    • 1
  • M. Dernovšek
    • 1
  • D. Sket
    • 1
  1. 1.Institute of PathophysiologyMedical SchoolLjubljanaYugoslavia

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