Experientia

, Volume 41, Issue 11, pp 1464–1465 | Cite as

In vitro mutagenicity testing of a potent, new, benzoyl urea insect growth regulator

  • A. Retnakaran
  • T. J. Ennis
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Summary

Bacterial mutagenicity assay to detect potential chronic toxicity of a potent, new, benzoyl urea insect growth regulator (CGA-112913 or IKI-7899, formerly UC-62644) was conducted using 5 histidine auxotrophs ofSalmonella typhimurium. Tests within the concentration range of 0.9–500 μg (saturating)/plate of the compound with and without the 5–9 mammalian metabolic activation system showed no mutagenic effects clearing the way for long-term chronic toxicology studies.

Key words

Benzoyl urea insect growth regulator Ames test histidine auxotrophs Salmonella typhimurium 

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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • A. Retnakaran
    • 1
  • T. J. Ennis
    • 1
  1. 1.Forest Pest Management InstituteCanadian Forestry ServiceSault Ste MarieCanada

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