Skip to main content
SpringerLink
Log in

Antidiuretic effects of oxytocin in the Brattleboro rat

  • Short Communications
  • Published:
Experientia Aims and scope Submit manuscript

Summary

The antidiuretic activity of oxytocin (OT) was measured in Brattleboro rats with congenital diabetes insipidus. A dose dependent antidiuretic response was found in animals receiving chronic infusions of 0.1 μg/h, 1.0 μg/h, and 5 μg/h of OT. OT infused at the rate of 5 μg/h over a 7-day period completely reversed the symptoms of diabetes insipidus. The results support the concept that OT serves as a weak agonist of vasopressin at the level of the kidney and at pharmacological levels exhibits antidiuretic activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Sawyer, W.H., and Valtin, H., Endocrinology80 (1967) 207.

    Article  CAS  PubMed  Google Scholar 

  2. Gellai, M., LaRochelle, F.T., and Valtin, H., in: Hormonal Regulation by Sodium Excretion, p. 121. Eds B. Lichardus, R.W. Schrier and J. Ponec. Elsevier/North Holland Biomedical Press, Amsterdam 1980.

    Google Scholar 

  3. Edwards, B.R., LaRochelle, F.T. Jr, and Gellai, M., Ann. N.Y. Acad. Sci.394 (1982) 497.

    Article  CAS  PubMed  Google Scholar 

  4. Forsling, M.L., Brimble, M.J., and Balment, R.J., Acta endocr.100 (1982) 216.

    CAS  PubMed  Google Scholar 

  5. Peters, G., and Roch-Ramel, F., Int. Ency. Pharm. Ther., section 41, vol. 1 (1970) 229.

    Google Scholar 

  6. Valtin, H., Am. J. Med.42 (1967) 814.

    Article  CAS  PubMed  Google Scholar 

  7. Balment, R.J., Brimble, M.J., and Forsling, M.L., Ann. N.Y. Acad. Sci.394 (1982) 241.

    Article  CAS  PubMed  Google Scholar 

  8. Gash, D.M., Sladek, C.D., and Sladek, J.R. Jr, Peptides1, suppl. 1 (1980) 125.

    Article  CAS  Google Scholar 

  9. Sladek, J.R. Jr, and Gash, D.M., in: Neural transplants: Development and Function, p. 243. Eds J.R. Sladek, Jr, and D.M. Gash. Plenum, New York 1984.

    Chapter  Google Scholar 

  10. Amico, J.A., Seif, S.M., and Robinson, A.G., J. clin. Endocr. Metab.52 (1981) 988.

    Article  CAS  PubMed  Google Scholar 

  11. Gash, D.M., Warren, P.H., Dick, L.B., Sladek, J.R. Jr, and Ison, J.R., Ann. N.Y. Acad. Sci.394 (1982) 672.

    Article  CAS  PubMed  Google Scholar 

  12. Robinson, I.C.A.F., Clark, R.G., Fairhall, K.M., Jones, P.M., and Parsons, J.A., Ann. N.Y. Acad. Sci.394 (1982) 285.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anatomy, University of Rochester School of Medicine, 14642, Rochester, New York, USA

    J. Lyness, A. G. Robinson, M. N. Sheridan & D. M. Gash

  2. Department of Medicine, University of Pittsburgh School of Medicine, 15261, Pittsburgh, Pennsylvania, USA

    J. Lyness, A. G. Robinson, M. N. Sheridan & D. M. Gash

  3. Department of Anatomy, Uniformed Services, University of the Health Sciences, 20814, Bethesda, Maryland, USA

    J. Lyness, A. G. Robinson, M. N. Sheridan & D. M. Gash

Authors
  1. J. Lyness
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. G. Robinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. N. Sheridan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. M. Gash
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lyness, J., Robinson, A.G., Sheridan, M.N. et al. Antidiuretic effects of oxytocin in the Brattleboro rat. Experientia 41, 1444–1446 (1985). https://doi.org/10.1007/BF01950026

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01950026

Key words

Search

Navigation