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Experientia

, Volume 41, Issue 11, pp 1409–1410 | Cite as

Benzamide potentiation of behavioral apomorphine-induced effects; mechanism involved

  • F. Piriou
  • J. Y. Petit
  • L. Welin
Short Communications

Summary

A new N-pyridinyl benzamide was found to potentiate strongly the effects of apomorphine on the motility of reserpinized mice and on circling behavior. Since dopaminergic agonist activity could not account for this potentiation, involvement ofβ-adrenergic agonist activity provided the only consistent explanation.

Key words

Apomorphine-induced behavior N-pyridinyl benzamide β-adrenergic agonists 

References

  1. 2.
    Ernst, A., Psychopharmacologia10 (1967) 316.Google Scholar
  2. 3.
    Puech, A. J., Rioux, P., Poncelet, M., Brochet, D., Chermat, R., and Simon, P., Neuropharmacology20 (1981) 1279.Google Scholar
  3. 4.
    Strömbom, U., Naunyn Schmiedebergs Arch. Pharmak.292 (1976) 167.Google Scholar
  4. 5.
    Von Voigtlander, P. F., and Moore, K. E., Neuropharmacology12 (1973) 451.Google Scholar
  5. 6.
    Pycock, C. J., Jenner, P. G., and Marsden, C. D., Naunyn Schmiedebergs Arch. Pharmak.297 (1977) 133.Google Scholar
  6. 7.
    Pycock, C. J., Neuroscience5 (1980) 461.Google Scholar
  7. 8.
    Kaakola, S., Acta Pharmac. Toxic.48 (1981) 162.Google Scholar
  8. 9.
    Anden, N. E., Strömbom, U., and Svensson, T. H., Psychopharmacologia29 (1973) 289.Google Scholar
  9. 10.
    Dorsey, W. S., and Easterly, W. D., J. pharm. Sci.60 (1971) 1723.Google Scholar
  10. 11.
    Protais, P., and Costentin, J., J. Pharmac.7, (1976) 251.Google Scholar
  11. 12.
    Berridge, T., Gadie, B., Roach, A. G., and Tulloch, J. F., Br. J. Pharmac.75 (1982) 49P.Google Scholar
  12. 13.
    Chance, W. T., Life Sci.33 (1983) 2241.Google Scholar
  13. 14.
    Hanson, L., Psychopharmacologia11 (1967) 8.Google Scholar
  14. 15.
    Goldberg, M. R., and Robertson, D., Pharmac. Rev.35 (1983) 143.Google Scholar
  15. 16.
    Pastor, G., Fallon, S., Welch, J. J., and Liebman, J. M., Eur. J. Pharmac.87 (1983) 459.Google Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • F. Piriou
    • 1
  • J. Y. Petit
    • 1
  • L. Welin
    • 1
  1. 1.Laboratoire de PharmacodynamieU.E.R. des Sciences PharmaceutiquesNantesFrance

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