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Evidence for an inhibitory role of β-endorphin and other opioids on human total T rosette formation

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Summary

β-endorphin, met-enkephalin, leu-enkephalin and morphine significantly inhibit rosette formation between human T lymphocytes and sheep red blood cells. This effect is completely reversed by naloxone, a specific antagonist, while naloxone by itself does not influence rosette formation. A further link between the immune system and the neuroendocrine system is suggested.

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References

  1. Geber, W.F., Lefkowitz, S.S., and Hung, C.Y., J. Toxic. environ. Hlth2 (1977) 577.

    CAS  Google Scholar 

  2. Geber, W.F., Lefkowitz, S.S., and Hung, C.Y., Pharmacology14 (1976) 322.

    Article  CAS  PubMed  Google Scholar 

  3. Marks, M.J., and Medzihradsky, F., Molec. Pharmac.10 (1974) 837.

    CAS  Google Scholar 

  4. Grube, D., Histochemistry69 (1980) 157.

    Article  CAS  PubMed  Google Scholar 

  5. Julliard, J.H., Shibasaki, T., Ling, N., and Guillemin, R., Science28 (1980) 183.

    Article  Google Scholar 

  6. Smith, E.M., Blalock, J.E., Proc. natl. Acad. Sci. USA78 (1981) 7530.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hazum, E., Chang, K.J., and Cuatrecasas, P., Science205 (1979) 1033.

    Article  CAS  PubMed  Google Scholar 

  8. Schweigerer, L., Bhakdi, S., and Teschemacher, H., Nature296 (1982) 572.

    Article  CAS  PubMed  Google Scholar 

  9. Gilman, S.C., Schwartz, J.M., Milner, R.J., Bloom, F.E., and Feldman, J.D., Proc. natl Acad. Sci. USA79 (1982) 4226.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. McDonough, R.J., Madden, J.J., Falek, A., Shafer, D.A., Pline, M., Gordon, D., Bokos, P., Kuehnle, J.C., and Mendelson, J., J. Immun.125 (1980) 2539.

    Article  CAS  PubMed  Google Scholar 

  11. Wybran, J., Appelboom, T., Famaey, J.P., and Govaertz, A., J. Immun.123 (1979) 1068.

    Article  CAS  PubMed  Google Scholar 

  12. Colt, E.W., Sharon, L.W., and Frantz, A.G., Life Sci.28 (1981) 1637.

    Article  CAS  PubMed  Google Scholar 

  13. Carr, D.B., Bullen, B.A., Skriner, G.S., Arnold, M.A., Rosenblatt, M., Beitins, I.Z., Martin, J.B., and McArthur, J., New Engl. J. Med.305 (1981) 560.

    Article  CAS  PubMed  Google Scholar 

  14. Fraioli, F., Moretti, C., Paolucci, D., Alicicco, E., Crescenzi, F., and Fortunio, G., Experientia36 (1980) 987.

    Article  CAS  PubMed  Google Scholar 

  15. Csontos, K., Rust, M., Hollt, V., Mahr, W., Kromer, W., and Teschemacher, H.J., Life Sci.25 (1979) 835.

    Article  CAS  PubMed  Google Scholar 

  16. Tonietti, G., Pecci, G., Liberatore, C., Salsano, F., and Fontana, L., Br. J. Haemat.30 (1975) 71.

    Article  CAS  Google Scholar 

  17. Tonietti, G., Pecci, G., d'Acunto, G., Lioy, E., Mercalli, M.E., Perricone, R., and Fontana, L., Experientia31 (1975) 1464.

    Article  CAS  PubMed  Google Scholar 

  18. Johnson, H.M., Smith, E.M., Torres, B.A., and Blalock, E.J., Proc. natl Acad. Sci. USA79 (1982) 4171.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Brouet, J.C., and Toben, H., J. Immun.116 (1976) 1041.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Clinica Medica VI and Clinica Medica V, University of Rome, Viale del Policlinico, I-00161, Rome, Italy

    C. De Carolis, G. De Sanctis, R. Perricone, C. Moretti, A. Fabbri, L. Gnessi, F. Fraioli & L. Fontana

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  1. C. De Carolis
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  2. G. De Sanctis
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  3. R. Perricone
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  4. C. Moretti
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  5. A. Fabbri
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  6. L. Gnessi
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  7. F. Fraioli
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  8. L. Fontana
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Additional information

Acknowledgments. We thank Dr C.B. Pert, NIH, Bethesda Md., for critical revision of this manuscript. We are indebted to Mr S. Marziali for valuable technical assistance.

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De Carolis, C., De Sanctis, G., Perricone, R. et al. Evidence for an inhibitory role of β-endorphin and other opioids on human total T rosette formation. Experientia 40, 738–739 (1984). https://doi.org/10.1007/BF01949751

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  • DOI: https://doi.org/10.1007/BF01949751

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