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Studies on three kinds of lectins fromXenopus laevis skin

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  • Biochemistry, Biophysics, Metabolism
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Summary

Among skin extracts of various frogs, lectin activity was found only in fractions prepared fromXenopus laevis skin. 3 skin lectins have been separated. Among these, the lectin designated S2-Dlc was isolated in a homogeneous state and showed a preferential agglutination of Ehrlich and S-180 ascites tumor cells; other tumor cells and human erythrocytes were not agglutinated. The lectin-dependent agglutination was inhibited by D-fucose, L-arabinose, D-galactose, lactose and lactulose. The sugar specificity of this lectin is similar to that of the lectin fromXenopus laevis eggs which agglutinates Ehrlich and S-180 ascites cells.

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Authors and Affiliations

  1. Cancer Research Institute, Tohoku College of Pharmaceutical Sciences, Komatsushima, 983, Sendai, Japan

    K. Nitta, G. Takayanagi, Y. Terasaki & H. Kawauchi

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  1. K. Nitta
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  2. G. Takayanagi
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  3. Y. Terasaki
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  4. H. Kawauchi
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Additional information

Acknowledgment. We thank Dr. S. Hakomori for his advice throughout this work and Dr. F.W. Symington for the critical reading of the manuscript.

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Nitta, K., Takayanagi, G., Terasaki, Y. et al. Studies on three kinds of lectins fromXenopus laevis skin. Experientia 40, 712–713 (1984). https://doi.org/10.1007/BF01949737

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  • DOI: https://doi.org/10.1007/BF01949737

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