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The inhibitory effect of D-glucosamine on thymidine kinase in chick embryo retinas and HeLa cells

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Summary

D-Glucosamine markedly inhibits thymidine incorporation into the TCA-insoluble fraction and thymidine kinase activity in HeLa cells. Both the inhibitory effects are also observed in isolated retinas of chick embryos. In this case the inhibitory effects are age-dependent and the magnitude of the responses decreases with embryonic development. In addition the time of exposure to D-glucosamine which is necessary to reveal the inhibitory effect on thymidine kinase increases with the age of the embryos.

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Authors and Affiliations

  1. Istituto di Chimica Biologica, Università di Palermo, Policlinico, I-90127, Palermo, Italy

    G. Tesoriere, L. Tesoriere, R. Vento, M. Giuliano & G. Cantoro

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  1. G. Tesoriere
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  2. L. Tesoriere
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  3. R. Vento
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  4. M. Giuliano
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  5. G. Cantoro
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Tesoriere, G., Tesoriere, L., Vento, R. et al. The inhibitory effect of D-glucosamine on thymidine kinase in chick embryo retinas and HeLa cells. Experientia 40, 705–707 (1984). https://doi.org/10.1007/BF01949733

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  • DOI: https://doi.org/10.1007/BF01949733

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