, Volume 40, Issue 7, pp 700–701 | Cite as

Acute physiological responses during blood substitution with colloidal gelatin in conscious rats

  • K. C. Lowe
  • D. C. McNaughton
Short Communications Physiology, Pathophysiology


The effects of exchange-transfusion with a proprietary gelatin-based plasma volume expander, Haemaccel, have been investigated in conscious, chronically-catheterized rats. No adverse changes in basic cardiovascular or respiratory functions occurred during the procedure although an increase in intravascular fluid sodium but not potassium concentration was observed.


Sodium Potassium Gelatin Physiological Response Volume Expander 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    The Haemaccel used in these studies was kindly donated by Mr N. Cockburn, Hoechst Pharmaceuticals, Hounslow, UK.Google Scholar
  2. 2.
    Geyer, R.P., Fedn Proc.34 (1975) 1525.Google Scholar
  3. 3.
    Riess, J.G., and LeBlanc, M., Angew. Chem.17 (1978) 621.CrossRefGoogle Scholar
  4. 4.
    Naito, R., and Yokoyama, K., in: Perfluorochemical blood substitutes, Green Cross Tech. Inform., Ser. No. 5. Green Cross Corp. Osaka 1978.Google Scholar
  5. 5.
    Fournier, G., Barrois, V., Girard, C., Robert, D., and Foulleteir, L., Experientia36 (1980), 568.PubMedGoogle Scholar
  6. 6.
    Baldwin, J.E., and Gill, B., Med. Lab. Sci.29 (1982) 45.Google Scholar
  7. 7.
    Lowe, K.C., Biologist30 (1983) 105.Google Scholar
  8. 8.
    Lowe, K.C., McNaughton, D.C., and Hardy, R.N., in: Oxygen-carring colloidal blood substitutes, p. 91. Eds R. Frey, H. Beisbarth and K. Stosseck. W. Zuckschwerdt Verlag, Munich 1982.Google Scholar
  9. 9.
    Snedecor, G.W., and Cochran, W.G., in: Statistical methods, 6th edn. Iowa State College Press, Ames 1967.Google Scholar
  10. 10.
    Ringler, D.H., and Dabich, L., in: The laboratory rat, vol. 1, p. 105. Eds H.J. Baker, J.R. Lindsey and S.H. Weisbroth. Academic Press, New York 1979.Google Scholar
  11. 11.
    Walsh, G.M., Ferrone, R.A., Tsuchiyu, M., Woodsand, E.F., and Deland, E.C., Am. J. Physiol.239 (1980) H805.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag Basel 1984

Authors and Affiliations

  • K. C. Lowe
    • 1
    • 2
  • D. C. McNaughton
    • 1
    • 2
  1. 1.Department of ZoologyUniversity of Nottingham University ParkNottingham(UK)
  2. 2.Department of SurgeryAddenbrooke's HospitalCambridge(UK)

Personalised recommendations