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Experientia

, Volume 38, Issue 3, pp 385–386 | Cite as

Different effects of the H2-antagonists on gastric emptying in the rat

  • G. Bertaccini
  • C. Scarpignato
Specialia

Summary

H2-receptor antagonists, in doses capable of inhibiting gastric secretion, did not generally affect gastric emptying. Exceptions were burimamide, which delayed the emptying rate, and ranitidine, which accelerated it. At higher doses burimamide, metiamide cimetidine and oxmetidine delayed gastric emptying, but ranitidine accelerated it to a greater extent. Tiotidine remained ineffective. These data suggest that changes in emptying rate are independent of the H2-receptor blockade.

Keywords

Cimetidine Gastric Emptying Ranitidine Gastric Secretion Metiamide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • G. Bertaccini
    • 1
  • C. Scarpignato
    • 1
  1. 1.Institute of PharmacologyUniversity of ParmaParma(Italy)

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