, Volume 38, Issue 3, pp 385–386 | Cite as

Different effects of the H2-antagonists on gastric emptying in the rat

  • G. Bertaccini
  • C. Scarpignato


H2-receptor antagonists, in doses capable of inhibiting gastric secretion, did not generally affect gastric emptying. Exceptions were burimamide, which delayed the emptying rate, and ranitidine, which accelerated it. At higher doses burimamide, metiamide cimetidine and oxmetidine delayed gastric emptying, but ranitidine accelerated it to a greater extent. Tiotidine remained ineffective. These data suggest that changes in emptying rate are independent of the H2-receptor blockade.


Cimetidine Gastric Emptying Ranitidine Gastric Secretion Metiamide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 2.
    G. Bertaccini, C. Scarpignato and G. Coruzzi, in: H2-antagonists, p. 251. Ed. A. Torsoli, P. E. Lucchelli and R. W. Brimblecombe. Excerpta Medica, Amsterdam 1980.Google Scholar
  2. 3.
    G. Bertaccini, G. Coruzzi, M. Molina and M. Chiavarini, Rend. Gastroenterol.9, 163 (1977).Google Scholar
  3. 4.
    G. Bertaccini, R. De Castiglione and C. Scarpignato, Br. J. Pharmac.72, 221 (1981).Google Scholar
  4. 5.
    C. Scarpignato, T. Capovilla and G. Bertaccini, Archs int. Pharmacodyn. Thér.246, 286 (1980).Google Scholar
  5. 6.
    C. Scarpignato and G. Bertaccini, Digestion21, 104 (1981).Google Scholar
  6. 7.
    G. Bertaccini and G. Dobrilla, Ital. J. Gastroenterol.12, 309 (1980).Google Scholar
  7. 8.
    P. T. Ridley, W. G. Groves, J. H. Schlosser and J. S. Massenberg, in: Proceedings of International Sympsium on Histamine H2-receptor antagonists, p. 259. Ed. C. J. Wood and M. A. Simkins. Deltakos Ltd, London 1973.Google Scholar
  8. 9.
    J. W. Black and K. E. V. Spencer, in: Proceedings of International Symposium on Histamine H2-receptor antagonists, p. 23. Ed. C. J. Wood and M. A. Simkins. Deltakos Ltd, London 1973.Google Scholar
  9. 10.
    R. W. Brimblecombe, W. A. M. Duncan, G. J. Durant and J. C. Emmett, J. intern. Med. Res.3, 86 (1975).Google Scholar
  10. 11.
    R. C. Blakemore, T. H. Brown, G. J. Durant, J. C. Emmett, C. R. Ganellin, M. E. Parsons and A. C. Rasmussen, Br. J. Pharmac.70, 105P (1980).Google Scholar
  11. 12.
    G. Bertaccini and G. Coruzzi, Farmaco Ed. Sc.36, 129 (1981).Google Scholar
  12. 13.
    G. Coruzzi, C. Scarpignato, L. Zappia and G. Bertaccini, Farmaco Ed. Sci.35, 466 (1980).Google Scholar
  13. 14.
    T. Yeo, G. Delitala, G. M. Besser and C. R. W. Edwards, Br. J. clin. Pharmac.10, 171 (1980).Google Scholar
  14. 15.
    S. Okabe, K. Takeuchi, T. Murata and K. Takagi, Eur. J. Pharmac.41, 205 (1977).Google Scholar
  15. 16.
    W. P. Pare, G. B. Glavin and G. P. Vincent, Pharmac. Biochem. Behav.8, 711 (1978).Google Scholar
  16. 17.
    K. T. Bunce, N. M. Clayton, M. J. Daly, J. M. Humphary and R. Stables, Br. J. Pharmac.70, 178P (1980).Google Scholar

Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • G. Bertaccini
    • 1
  • C. Scarpignato
    • 1
  1. 1.Institute of PharmacologyUniversity of ParmaParma(Italy)

Personalised recommendations