, Volume 38, Issue 3, pp 369–370 | Cite as

Stimulation of H+ ion secretion from the isolated mouse stomach by sodium fluoride

  • E. S. K. Assem
  • B. Y. C. Wan


The effect of sodium fluoride on H+ ion secretion was investigated in the isolated distended mouse stomach. It was found that sodium fluoride on its own caused dose-related stimulation of H+ ion secretion. Sodium fluoride did not inhibit H+ ion secretion induced by histamine. The possible mechanisms involved are discussed. It is considered that sodium fluoride might stimulate H+ ion secretion by causing histamine release and by increasing cyclic AMP formation in the intact gastric mucosa.


Sodium Fluoride Histamine Gastric Mucosa Histamine Release 
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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • E. S. K. Assem
    • 2
  • B. Y. C. Wan
    • 1
  1. 1.Department of PharmacologyUniversity College LondonLondon(England)
  2. 2.Department of PharmacologyBiorex Research Laboratories LtdLondon(England)

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