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Toxic effects of Zn++ and Cu++ on mouse blastocysts in vitro

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Summary

Mouse blastocysts were cultured in the presence of zinc and/or cupric chloride at various concentrations. Cupric ions were superior to Zn++ at inhibiting hatching of blastocysts from their zona pellucida and formation of trophoblastic outgrowths. Protein in the medium protected embryos from the toxic effects of zinc and copper.

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References

  1. J. K. Campbell and C. F. Mills, Proc. Nutr. Soc.33, 15A (1974).

    CAS  PubMed  Google Scholar 

  2. H. D. Ritchie, R. W. Lueke, B. V. Baltzer, E. R. Miller, D. E. Ullrey and J. A. Hoefer, J. Nutr.79, 117 (1963).

    Article  CAS  PubMed  Google Scholar 

  3. C. H. Hill and G. Matrone, Fedn Proc.29, 1474 (1970).

    CAS  Google Scholar 

  4. N. F. Sittle and C. F. Mills, Br. J. Nutr.20, 135 (1966).

    Article  Google Scholar 

  5. N. T. Davies, Proc. Nutr. Soc.35, 293 (1974).

    Article  Google Scholar 

  6. N. T. Davies, Proc. Nutr. Soc.38, 121 (1979).

    Article  CAS  PubMed  Google Scholar 

  7. I. Bremner and N. T. Davies, Biochem. Soc. Trans.2, 425 (1974).

    Article  CAS  Google Scholar 

  8. D. R. Van Campen and P. U. Scaife, J. Nutr.91, 473 (1967).

    Article  PubMed  Google Scholar 

  9. D. R. Van Campen, J. Nutr.97, 104 (1969).

    Article  PubMed  Google Scholar 

  10. R. L. Brinster and P. C. Cross, Nature238, 398 (1972).

    Article  CAS  PubMed  Google Scholar 

  11. G. Naeslund, Contraception6, 281 (1972).

    Article  CAS  Google Scholar 

  12. M. K. Holland and I. L. Pike, J. Reprod. Fert.53, 335 (1978).

    Article  CAS  Google Scholar 

  13. F. B. Orlans, Contraception10, 543 (1974).

    Article  CAS  PubMed  Google Scholar 

  14. C. C. Chang, H. J. Tatum and F. A. Kincl, Fert. Steril.21, 274 (1970).

    Article  CAS  Google Scholar 

  15. D. Gallaher and L. S. Hurley, J. Nutr.110, 591 (1980).

    Article  CAS  PubMed  Google Scholar 

  16. R. E. Fowler and R. G. Edwards, J. Endocr.15, 374 (1957).

    Article  CAS  PubMed  Google Scholar 

  17. L. J. Van Winkle, Biochem. biophys. Res. Commun.98, 562 (1981).

    Article  PubMed  Google Scholar 

  18. L. J. Van Winkle, J. exp. Zool.218, 239 (1981).

    Article  PubMed  Google Scholar 

  19. C. M. Woolf, ed., in: Principles of Biometry, p. 302. D. Van Nostrand, London 1968.

    Google Scholar 

  20. L. S. Hurley and R. E. Shrader, Nature254, 427 (1975).

    Article  CAS  PubMed  Google Scholar 

  21. A. I. Spindle and R. A. Pedersen, J. exp. Zool.186, 305 (1979).

    Article  Google Scholar 

  22. Y-C. Hsu, Devl Biol.68, 453 (1979).

    Article  CAS  Google Scholar 

  23. M. H. Sellens and M. I. Sherman, J. Embryol. exp. Morph.56, 1 (1980).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Chicago College of Osteopathic Medicine, 1122 East 53rd Street, 60615, Chicago, Illinois, USA

    L. J. Van Winkle & A. L. Campione

Authors
  1. L. J. Van Winkle
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  2. A. L. Campione
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Additional information

Acknowledgment. The authors wish to thank Dr W. E. Farnsworth, Dr D. F. Mann, Mr H. Wasserlauf and Ms Barb Le Breton for their help in producing this manuscript. Supported by the Chicago College of Osteopathic Medicine.

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Van Winkle, L.J., Campione, A.L. Toxic effects of Zn++ and Cu++ on mouse blastocysts in vitro. Experientia 38, 354–356 (1982). https://doi.org/10.1007/BF01949389

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