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The efficacy of a novel compound, (E)-1-(4′-bromo-4-biphenylyl)-1-(4-chlorophenyl)-3-dimethylaminoprop-1-ene againstTrypanosoma cruzi in mice

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Summary

The biological properties of a novel compound 353C with high activity againstTrypanosoma cruzi, are described. The compound was about 10 times and 20 times more effective than either benznidazole or nifurtimox respectively, in producing radical cure in mice. 353C had a long half-life and showed anti-trypanosomal properties when given to mice at weekly intervals.

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References

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Authors and Affiliations

  1. Wellcome Research Laboratories, Langley Court, BR3 3BS, Beckenham, kent, England

    P. A. Barrett, Elizabeth Beveridge, D. Bull, I. C. Caldwell, P. J. Islip, R. A. Neal & N. C. Woods

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  1. P. A. Barrett
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  2. Elizabeth Beveridge
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  3. D. Bull
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  4. I. C. Caldwell
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  5. P. J. Islip
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  6. R. A. Neal
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  7. N. C. Woods
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Barrett, P.A., Beveridge, E., Bull, D. et al. The efficacy of a novel compound, (E)-1-(4′-bromo-4-biphenylyl)-1-(4-chlorophenyl)-3-dimethylaminoprop-1-ene againstTrypanosoma cruzi in mice. Experientia 38, 338–339 (1982). https://doi.org/10.1007/BF01949378

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  • DOI: https://doi.org/10.1007/BF01949378

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