Experientia

, Volume 38, Issue 3, pp 337–338 | Cite as

Prianicin A and B, nor-sesterterpenoid peroxide antibiotics from red sea sponges

  • S. Sokoloff
  • S. Halevy
  • Varda Usieli
  • A. Colorni
  • S. Sarel
Specialia

Summary

The antibiotic properties of 2 acidic C24H40O4 nor-sesterterpenoid peroxides, prianicin A (1) and B (2), against gram-positive and gram-negative bacteria, and against fungi are herein described. They are 4–10 times more effective than tetracycline againstbeta hemolytic Streptococcus, but significantly non-effective against a variety of gram-negative bacteria.

Keywords

Peroxide Sponge Tetracycline Hemolytic Streptococcus Antibiotic Property 

References

  1. 4.
    B. Franco, M. Tsurnamal, A. Colorni and S. Halevy. in preparation.Google Scholar
  2. 5.
    Prianos sp. of the familyHymeniacidonidae, identified by Dr M. Tzurnamal of the Zoology Department, Hebrew University of Jerusalem.Google Scholar
  3. 6.
    W.C. Still, M. Kahn and A. Mitra, J. org. Chem.43, 2923 (1978).Google Scholar
  4. 7.
    Y. Kashman and M. Rotem, Tetrahedron Lett.1979, 1707.Google Scholar
  5. 8.
    S. Sokoloff, I. Tamir, S. Halevy and S. Sarel, submitted.Google Scholar
  6. 9a).
    M. Albericci, J.C. Braekman, D. Daloze and B. Tursch, 3rd int. Symp. Marine nat. Prod., p. P-14. Bruxelles, Sept. 1980, abstracts;Google Scholar
  7. 9b).
    M. Albericci, M. Collart-Lempereur, J.C. Braekman, D. Daloze, B. Tursch, J.P. Declercq, G. Germain and M. Van Meersche, Tetrahedron Lett.1979, 2687.Google Scholar
  8. 10.
    M.C. Bryant, Antibiotics and their Laboratory Control, Butterworths, London 1972.Google Scholar

Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • S. Sokoloff
    • 1
  • S. Halevy
    • 1
  • Varda Usieli
    • 1
  • A. Colorni
    • 1
  • S. Sarel
    • 1
  1. 1.Department of Pharmaceutical ChemistryThe Hebrew University School of PharmacyJerusalem(Israel)

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