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Double-contrast enema in antibiotic-related pseudomembranous colitis

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Abstract

Pseudomembranous colitis (PMC) is a potentially fatal disease often associated with antibiotic therapy. The condition is now known to be due to an enterotoxin produced byClostridium difficile. Diagnosis is based on the endoscopic finding of the typical pseudomembranes, stool culture, and assay of the stools for the specific toxin. Radiography with double-contrast medium (DCE), which can be performed in patients not critically ill, often yields pathognomonic findings and permits early diagnosis.

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References

  1. Bartlett JG, Moon N, Chang TW, Taylor N, Onderdonk AB: Role ofClostridium difficile in antibiotic-associated pseudomembranous colitis.Gastroenterology 75:778–782, 1978

    PubMed  Google Scholar 

  2. Hyson EA, Burrell M, Toffler R: Drug-induced gastrointestinal disease.Gastrointest Radiol 2:183–212, 1977

    Article  PubMed  Google Scholar 

  3. Kappas A, Shinagawa N, Arabi Y, Thompson H, Burdon DW, Dimock F, George RH, Alexander-Williams J, Keighley MRB: Diagnosis of pseudomembranous colitis.Brit Med J 1:675–678, 1978

    PubMed  Google Scholar 

  4. Keighley MRB, Burdon DW, Alexander-Williams J, Shinagawa N, Arabi Y, Thompson H, Youngs D, Bentley S: Diarrhoea and pseudomembranous colitis after gastrointestinal operations.Lancet 2:1165–1167, 1978

    Article  PubMed  Google Scholar 

  5. Viscidi R, Willey S, Bartlett JG: Isolation rates and toxigenic potential ofClostridium difficile isolates from various patient populations.Gastroenterology 81:5–9, 1981

    PubMed  Google Scholar 

  6. Stanley RJ, Melson GL, Tedesco FJ, Saylor JL: Plain film findings in severe pseudomembranous colitis.Radiology 118:7–11, 1976

    PubMed  Google Scholar 

  7. Stanley RJ, Melson GL, Tedesco FJ: The spectrum of radiographic findings in antibiotic-related pseudomembranous colitis.Radiology 111:519–524, 1974

    PubMed  Google Scholar 

  8. Shimkin PM, Link RJ: Pseudomembranous colitis: a consideration in the barium enema differential diagnosis of acute generalized ulcerative colitis.Br J Radiol 46:437–439, 1973

    PubMed  Google Scholar 

  9. Keighley MRB, Burdon DW, Arabi Y, Alexander-Williams J, Thompson H, Youngs D, Johnson M, Bentley S, George RH, Mogg GAG: Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhoea.Br Med J 2:1667–1669, 1978

    PubMed  Google Scholar 

  10. Chang TW, Gorbach SL, Bartlett JG, Saginur R: Bacitracin treatment of antibiotic-associated colitis and diarrhea caused byClostridium difficile toxin.Gastroenterology 78:1584–1586, 1980

    PubMed  Google Scholar 

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Strada, M., Meregaglia, D. & Donzelli, R. Double-contrast enema in antibiotic-related pseudomembranous colitis. Gastrointest Radiol 8, 67–69 (1983). https://doi.org/10.1007/BF01948091

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