This report describes a patient with carcinoid metastatic to the liver in whom a hepatic artery catheter was placed for infusion therapy. This resulted in a previously unreported complication of a hepatic artery-biliary fistula. The clinical presentation of this complication and mode of management are described. The etiologic factors responsible for this complication are discussed. It is speculated that as more aggressive therapy for hepatic metastases is undertaken, this potential complication will be seen more frequently.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Bengmark S, Rosengren K: Angiographic study of the collateral circulation to the liver after ligation of the haptic artery in man.Am J Surg 119:620–624, 1970
Breedis C, Young G: The blood supply of neoplasms in the liver.Am J Pathol 30:969–975, 1954
Fortner JG, Mulcare RJ, Solis A, Watson RC, Golbey RB: Treatment of primary and secondary liver cancer by hepatic artery ligation and infusion chemotherapy.Ann Surg 178:162–172, 1973
Foster JH, Bermna MM: Solid liver tumors.Major Probl Clin Surg 22:1–342, 1977
Gelin LE, Lewis DH, Nilsson L: Liver blood flow in man during abdominal surgery. II. The effect of hepatic artery occlusion on the blood flow through metastatic tumor nodules.Acta Hepatogastroenterol (Stuttg) 15:21–24, 1968
Goldner F: Hemobilia secondary to metastatic liver disease.Gastroenterol 76:595–598, 1979
Moertel CG: Chemotherapy of colorectal cancer. In: Enker WE (ed):Carcinoma of the Colon and Rectum. Chicago, London: Year Book Medical Publishers, 1978, pp 172–186
Mori W, Masuda M, Miyanage T: Hepatic artery ligation and tumor necrosis in the liver.Surgery 59:359–363, 1966
Nilsson LAV: Therapeutic hepatic artery ligation in patients with secondary liver tumors.Rev Surg 23:374, 1966
Oberfield RA, McCaffrey JA, Polio J, Clouse ME, Hamilton T: Prolonged and continuous percutaneous intra-arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary.Cancer 44:414–423, 1979
Plengvanit U, Chearanai O, Sindhvananda K, Damrongsak D, Tuchinda S, Viranuvatti V: Collateral arterial blood supply of the liver after hepatic artery ligation, angiographic study of twenty patients.Ann Surg 175:105–110, 1972
Reed ML, Vaitkevicus VK, Al-Sarraf M, Vaugh CB, Singhakowinta A, Sexon-Porte M, Izbicki R, Baker L, Straatsma GW: The practicality of clinic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: ten-year results of 124 patients in a prospective protocol.Cancer 48:402–409, 1981
Sandbloom P:Hemobilia. Springfield, Ill.: Charles C. Thomas Publisher, 1972
Silverberg E: Cancer statistics, 1977.CA 27:26–41, 1977
Sparks FC, Mosher MB, Hallauer WG, Silverstein MJ, Rangel D, Passaro E Jr, Morton DL: Hepatic artery ligation and postoperative chemotherapy for hepatic metastases: clinical and pathophysiological results.Cancer 35:1074–1082, 1975
About this article
Cite this article
Rosenberg, H.D., Wile, A.G., Aufrichtig, D. et al. Hepatic artery-biliary fistula. An unusual complication of infusion therapy. Gastrointest Radiol 8, 37–40 (1983). https://doi.org/10.1007/BF01948085
- Hepatic artery-biliary fistula
- Infusion therapy
- Hepatic artery ligation
- Tumor necrosis