Abstract
The spongeDarwinella rosacea was found to harbor a host of marine microorganisms. One of these bacteria was identified as a marineAlteromonas species. The organic extract of this bacterium was antimicrobial, and the activity was traced to two novel pseudomonic acid derivatives1 and7. The structures of these compounds were elucidated by interpretation of the spectral data and extensive use of 2-dimensional NMR techniques and NOE studies on the parent compounds and the acetate derivatives2 and8.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Grayson, M., ed., Antibiotics, Chemotherapeutics, and Antibacterial Agents for Disease Control. John Wiley & Sons, New York 1982.
Lee, M. D., Dunne, T. S., Chang, C. C., Ellestad, G. A., Seigel, M. M., Morton, G. O., McGahren, W. J., and Borders, D. B., J. Am. chem. Soc.109 (1987) 3466.
Golik, J., Dubay, G., Groenewold, G., Kawaguchi, H., Konishi, M., Krishnan, B., Ohkuma, H., Saitoh, K., and Doyle, T. W., J. Am. chem. Soc.109 (1987) 3462.
Faulkner, D. J., Marine nat. Prod. Reports51 (1988) 613.
Blade-Font, A., Tetrahedron Lett.21 (1980) 2443.
Clayton, J. P., O'Hanlon, P. J., and Rogers, N. H., Tetrahedron Lett.21 (1980) 881.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stierle, D.B., Stierle, A.A. Pseudomonic acid derivatives from a marine bacterium. Experientia 48, 1165–1169 (1992). https://doi.org/10.1007/BF01948016
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01948016