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Protection by chlorpromazine against lethality and renal toxicity of cisplatin in mice

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Abstract

The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine given (i.p.) 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin. Chlorpromazine did not reduce the antitumor activity of cisplatin against Sarcoma 180 in ddY mice or EL-4 Leukemia in C57BL/6J mice.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku College of Pharmacy, 4-4-1 Komatsushima, Aoba-ku, 981, Sendai, Japan

    M. Ishikawa, M. Ozaki, Y. Takayanagi & K. Sasaki

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  1. M. Ishikawa
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  2. M. Ozaki
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  3. Y. Takayanagi
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  4. K. Sasaki
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Additional information

This work was partly supported by Grants-in-Aid from the Science Research Promotion Fund (Japan Private School Promotion Foundation).

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Ishikawa, M., Ozaki, M., Takayanagi, Y. et al. Protection by chlorpromazine against lethality and renal toxicity of cisplatin in mice. Experientia 48, 1142–1144 (1992). https://doi.org/10.1007/BF01948009

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  • DOI: https://doi.org/10.1007/BF01948009

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