, Volume 48, Issue 11–12, pp 1142–1144 | Cite as

Protection by chlorpromazine against lethality and renal toxicity of cisplatin in mice

  • M. Ishikawa
  • M. Ozaki
  • Y. Takayanagi
  • K. Sasaki
Research Articles


The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine given (i.p.) 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin. Chlorpromazine did not reduce the antitumor activity of cisplatin against Sarcoma 180 in ddY mice or EL-4 Leukemia in C57BL/6J mice.

Key words

Cisplatin chlorpromazine lethality renal toxicity mice 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Madidas, N. E., and Harrington, J. T., Am. J. Med.65 (1978) 307.Google Scholar
  2. 2.
    Ishikawa, M., Shiba, Y., Takayanagi, G., and Sasaki, K., A. Rep. Tohoku Coll. Pharm.34 (1987) 235.Google Scholar
  3. 3.
    Ishikawa, M., Mori, M., Sasaki, K., and Takayanagi, G., A. Rep. Tohoku Coll. Pharm.35 (1988) 261.Google Scholar
  4. 4.
    Carr, B., Bertrand, M., Browning, S., Dorowshow, J. H., Presant, C., Pulone, B., and Hill, L. H., J. clin. Oncol.3 (1985) 1127.Google Scholar
  5. 5.
    Harrison, S. D., Coox, J. L., and Giles, R. C., Cancer Chemother. Pharmac.10 (1982) 62.Google Scholar
  6. 6.
    Ishikawa, M., Sasaki, M., Sasaki, K., and Takayanagi, Y., Res. Commun. chem. Pathol. Pharmac.64 (1989) 347.Google Scholar
  7. 7.
    Borch, R. F., and Markman, M., Pharmac. Ther.41 (1989) 371.Google Scholar
  8. 8.
    Harrison, S. D., Cox, J. L., and Giles, R. C., Bull. envir. Contam. Toxic.34 (1985) 432.Google Scholar
  9. 9.
    Harrison, S. D., Mann, D. M., and Giles, R. C., Cancer Chemother. Pharmac.14 (1985) 146.Google Scholar
  10. 10.
    Prozialek, W. C., and Weiss, B., J. Pharmac. exp. Ther.222 (1982) 509.Google Scholar
  11. 11.
    Hait, W. N., and Lazo, J. S., J. clin. Oncol.4 (1986) 994.Google Scholar
  12. 12.
    Lazo, J. S., Hait, W. N., and Kennedy, K. A., Molec. Pharmac.27 (1985) 387.Google Scholar
  13. 13.
    Tsuruo, T., Lida, H., Tsukagoshi, S., Sakurai, T., Cancer Res.42 (1982) 4730.Google Scholar
  14. 14.
    Ganapathi, R., and Grabowski, D., Cancer Res.43 (1983) 3696.Google Scholar

Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • M. Ishikawa
    • 1
  • M. Ozaki
    • 1
  • Y. Takayanagi
    • 1
  • K. Sasaki
    • 1
  1. 1.Department of Pharmacology and Toxicology, Cancer Research InstituteTohoku College of PharmacySendai(Japan)

Personalised recommendations