Abstract
Piroxicam is a nonsteroidal anti-inflammatory drug with a potent analgesic effect. In order to establish whether the analgesic action of Piroxicam has a central component, we studied the effect of the drug on the nociceptive orbicularis oculi reflexes evoked by electrical stimulation of the cornea and supraorbital nerve in healthy subjects. Piroxicam significantly suppressed the corneal reflex and R3 component of the blink reflex by 28% (p<0.05) and 50% (p<0.01), respectively. This effect was not reversed by the i.v. injection of naloxone. Beta-endorphin levels did not change. Piroxicam administration induces distinct inhibitory changes in nociceptive reflexes, which suggests that the analgesic action of the drug has a central component. The ineffectiveness of naloxone, and the lack of beta-endorphin changes, indicate that this central action is independent of the opioid system; other pain regulatory systems are probably involved.
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References
Scherrer, R. A., in: Anti-inflammatory Agents, vol. 1, Eds R. A. Scherrer and M. W. Whitehouse. Academic Press, New York 1974.
Abraneson, S., Korchack, H., and Ludewig, R., Proc. natl Acad. Sci. USA82 (1985) 7227.
Martini, A., Bondiolotti, G. P., Sacerdote, P., Pierro, L., Picotti, G. B., Panerai, A. E., Restelli, L., Zancaner, F., and Monza, G., J. int. Med. Res.12 (1984) 92.
Sacerdote, P., Monza, G., Mantegazza, P., and Panerai, A. E., Pharmac. Res. Commun.17 (1985) 679.
Sunshine, A., Roure, C., Colon, A., Olson, N. Z., Gonzalez, L., Siegel, C., and Laska, E., Am. J. Med. Suppl. 5A (1988) 16.
Paeile, C., Lombard, M. C., Saavedra, H., Bustos, E., and Pelissier, T., Gen. Pharmac.20 (1989) 519.
Cruccu, G., Ferracuti, S., Leardi, M. G., Fabbri, A., and Manfredi, M., Brain Res.556 (1991) 209.
Fabbri, A., Knox, G., Buczko, E., and Dufau, M. L., Endocrinology122 (1988) 749.
Cruccu, G., Agostino, R., Berardelli, A., and Manfredi, M., Neurosci. Lett.63 (1986) 320.
Cruccu, G., Inghilleri, M., Fraioli, B., and Manfredi, M., Neurology37 (1987) 631.
Ongerboer De Visser, B. W., Adv. Neurol.39 (1983) 727.
Kimura, J., in: New Developments in Electromyography and Clinical Neurophysiology, vol. 3, p. 682. Ed. J. E. Desmedt. Karger, Basel 1973.
Dauthier, C., Gaudy, J. H., and Bonnet, P., Ann. Anesth. fr.4 (1981) 317.
Delwaide, P. J., Schoenen, J., and Burton, L., Adv. Neurol.39 (1983) 977.
Evinger, C., Sibony, P. A., and Manning, P. A., Exp. Brain Res.73 (1988) 477.
Cruccu, G., Ferracuti, S., Leardi, M. G., and Manfredi, M., Pain, suppl. 5 (1990) 5431.
Rossi, B., Risaliti, R., and Rossi, A., Electroenceph. clin. Neurophysiol.73 (1989) 334.
Panneton, W. M., and Burton, H., J. comp. Neurol.199 (1981) 327.
Okuyama, S., and Aihara, H., Jap. J. Pharmac.35 (1984) 95.
Chen, A. C. N., and Chapman, C. R., Exp. Brain Res.39 (1980) 359.
Willer, J. C., De Broucker, T., Bussel, B., Roby-Bramy, A., and Harrewyn, J. M., Pain38 (1989) 1.
Jurna, I., and Brune, K., Pain41 (1990) 71.
Marrazzi, M. A., and Daugherty, J. H., Prostaglandins14 (1977) 501.
Groppetti, A., Braga, P. C., Biella, G., Parenti, M., Rusconi, L., and Mantegazza, P., Neuropharmacology27 (1988) 499.
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Fabbri, A., Cruccu, G., Sperti, P. et al. Piroxicam-induced analgesia: Evidence for a central component which is not opioid mediated. Experientia 48, 1139–1142 (1992). https://doi.org/10.1007/BF01948008
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DOI: https://doi.org/10.1007/BF01948008