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Cyclosporine is angiostatic

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Abstract

The systemic effect of the immunosuppressive drug cyclosporine (CS) on formation of new blood vessels was studied quantitatively in rats using the mesenteric-window assay. Angiogenesis was induced by i.p. injection of saline. CS at a s.c. dose of 4 mg/kg/day, which is in the range used clinically, suppressed angiogenesis (inhibiting branching or tortuosity more than spatial expansion), and appeared to be non-toxic. This is the first report on an apparently selective angiostatic effect of CS. The finding is likely to have implications for the clinical use of CS, not only in certain types of organ transplantation but possibly also in psoriasis and other angiogenesis-dependent diseases.

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Authors and Affiliations

  1. Department of Pathology, University of Göteborg, S-41345, Göteborg, Sweden

    K. Norrby

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  1. K. Norrby
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Additional information

The generic name cyclosporine is used in accordance with the recommendation of the United States Adopted Name Council [Borel, J. F., Prog. Allergy38 (1986) 9]. Acknowledgments. This investigation was supported by the Swedish Medical Research Council, project No. 5942. We are indebted to Mrs Gunvor Jefferth and Miss Ann Nehlmark for their skilful technical assistance.

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Norrby, K. Cyclosporine is angiostatic. Experientia 48, 1135–1138 (1992). https://doi.org/10.1007/BF01948007

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