Skip to main content
SpringerLink
Log in

Lack of long term effect of p-chlorophenylalanine on brain 5-hydroxytryptamine and electrocortical activity in conscious fetal sheep

  • Short Communications
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Daily infusion of p-chlorophenylalanine (p-CPA) into unaesthetized fetal sheep for 3–6 days did not reduce brain 5-hydroxytryptamine (5-HT) concentrations or produce long-term changes in the pattern of electrocortical activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Clewlow, F., Dawes, G.S., Johnston, B.M., and Walker, D.W., J. Physiol.341 (1983) 463.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Jouvet, M., Physiol. Rev.47 (1967) 117.

    Article  CAS  PubMed  Google Scholar 

  3. Quilligan, E.J., Clewlow, F., Johnston, B.M., and Walker, D.W., Am. J. Obstet. Gynec.141 (1981) 271.

    Article  CAS  PubMed  Google Scholar 

  4. Dawes, G.S., Fox, H.E., Leduc, B.M., Liggins, G.C., and Richards, R.T., J. Physiol.220 (1972) 119.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Curzon, G., and Green, A.R., Br. J. Pharmac.39 (1970) 653.

    Article  CAS  Google Scholar 

  6. Tissari, A., Acta physiol. scand.67 (1966) suppl. 265.

  7. Koe, B.K. and Weissman, A., J. Pharm. exp. Ther.154 (1966) 499.

    CAS  Google Scholar 

  8. Koella, W.P., Feldstein, A., and Czicman, J.S., Electroenceph. clin. Neurophysiol.25 (1968) 481.

    Article  CAS  PubMed  Google Scholar 

  9. Weitzman, E.D., Rapport, M.M., McGregor, P., and Jacoby, J., Science160 (1968) 1361.

    Article  CAS  PubMed  Google Scholar 

  10. Koe, B.K., and Weissman, A., Adv. Pharmac.6B (1968) 29.

    Article  Google Scholar 

  11. Marley, E., and Whelan, J.E., Br. J. Pharmac.56 (1976) 133.

    Article  CAS  Google Scholar 

  12. Mouret, J., Bobillier, P., and Jouvet, M., Eur. J. Pharmac.5 (1968) 17.

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. B. M. Johnston

    Present address: Department of Paediatrics, School of Medicine, University of Auckland, Auckland 1, New Zealand

  2. D. W. Walker

    Present address: Department of Physiology, Monash University, 3168, Clayton, Victoria, Australia

Authors and Affiliations

  1. The Nuffield Institute for Medical Research, University of Oxford, OX39DS, Oxford, England

    B. M. Johnston, D. W. Walker & A. R. Green

  2. MRC Unit and University Department of Clinical Pharmacology, Radcliffe Infirmary, OX26HE, Oxford, England

    B. M. Johnston, D. W. Walker & A. R. Green

Authors
  1. B. M. Johnston
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. W. Walker
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. R. Green
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgments. This work was supported by an MRC grant to Professor G.S. Dawes, Nuffield Institute for Medical Research, Oxford. We thank C. Hanson and J. Deardon for help with the surgery and S. Lister for technical assistance.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Johnston, B.M., Walker, D.W. & Green, A.R. Lack of long term effect of p-chlorophenylalanine on brain 5-hydroxytryptamine and electrocortical activity in conscious fetal sheep. Experientia 40, 291–294 (1984). https://doi.org/10.1007/BF01947589

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01947589

Keywords

Search

Navigation