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Changes in cholinesterase activity of muscle after crushing the sciatic nerve of rats

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Summary

The subcellular distribution of cholinesterase (ChE) was studied in the gastrocnemius muscle of rats after strong or weak nerve crushing. The ChE activities of muscle were decreased to a greater extent by strong crushing than by weak crushing. In particular, the ChE activity of the fraction containing sarcoplasmic reticulum was most greatly decreased. These results suggest that the change in the ChE activity of the microsomal fraction most finely reflects the strength of nerve crushing.

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Authors and Affiliations

  1. Department of Chemistry, Sophia University, Chiyoda-ku, 102, Tokyo, (Japan)

    H. Kobayashi, K. Hasegawa, M. Tanaka & M. Kikuno

  2. Central Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, 140, Tokyo, (Japan)

    H. Kobayashi, K. Hasegawa, M. Tanaka & M. Kikuno

Authors
  1. H. Kobayashi
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  2. K. Hasegawa
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  3. M. Tanaka
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  4. M. Kikuno
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Additional information

Acknowledgments. This study was accomplished in Central Research Laboratories, Sankyo Co. Ltd. The authors wish to thank Prof. Tsuneyuki Nakazawa, Department of Neuropsychiatry, School of Medicine, Fujita-Gakuen University, and Dr Yutaka Sakai for their valuable advice and support, Sr Jean M. Michalec for her critical comments, and Miss Hamako Katano, Mr Naoji Mikuni and Miss Yoshie Ishii for their skillful technical assistance.

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Kobayashi, H., Hasegawa, K., Tanaka, M. et al. Changes in cholinesterase activity of muscle after crushing the sciatic nerve of rats. Experientia 34, 750–751 (1978). https://doi.org/10.1007/BF01947302

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  • DOI: https://doi.org/10.1007/BF01947302

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