Summary
Intracardiac injection gives proportionately higher and earlier peak concentration in tissues that specifically accumulates it, i.m. injection gives slower but longer lasting accumulations, and topical application to a ganglia essentially localizes the drug in that structure.
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References
E. Aiello and G. Guideri, J. Pharmac. exp. Ther.154, 517 (1966).
G.B. Stefano and E. Aiello, Biol. Bull.148, 141 (1975).
G.B. Stefano, E.J. Catapane and E. Aiello, Science194, 539 (1976).
G.B. Stefano, E.J. Catapane and J.M. Stefano, Biol. Bull.153, 618 (1977).
G.B. Stefano and E.J. Catapane. J. Pharmac. exp. Ther.203, 449 (1977).
C.B. Jorgensen, Ophelia13, 187 (1975).
E.J. Catapane, G.B. Stefano and E. Aiello, J. exp. Biol, in press (1978).
C.J. Malanga, G.R. Wenger and E. Aiello, Comp. Biochem. Physiol.43A, 825 (1972).
E. Aiello and G. Guideri, Biol. Bull.129, 431 (1965).
R.E. Gosselin, K.E. Moore and A.S. Milton, J. gen. Physiol.46, 277 (1962).
B. York and B.M. Twarog, Comp. Biochem. Physiol.44A, 423 (1973).
A. Dahlström, J. Häggendal and T. Hökfelt, Acta physiol. scand.67, 289 (1966).
J.E. Haley, G.B. Stefano and E.J. Catapane, Experientia34, 210 (1978).
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We wish to thank Drs Hiripi and Nemcsok for the demonstration of the intracardiac technique. We also wish to thank Drs Haley and Ledeen for the use of the scintillation counter.
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Stefano, G.B., Aiello, E. Distribution of radioactivity after administration of3H-5-hydroxytryptamine by three different routes to the musselMytilus edulis . Experientia 34, 749–750 (1978). https://doi.org/10.1007/BF01947301
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DOI: https://doi.org/10.1007/BF01947301