, Volume 34, Issue 6, pp 745–746 | Cite as

Bayliss myogenic response in the isolated ductus arteriosus of guinea-pig and rabbit fetuses

  • V. Smieško
  • M. Kriška
  • V. Kovalčík


Isolated ductus arteriosus responds by marked constriction to increases in perfusion pressure. If, however, these increases exceed 90 mm Hg-130 mm Hg, the vessel suddenly dilates and its responsiveness becomes depressed. The importance of these findings in postnatal closure of ductus arteriosus is discussed.


Perfusion Pressure Myogenic Response Rabbit Fetus Marked Constriction Postnatal Closure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    M.A. Heymann and A.M. Rudolph, Physiol. Rev.55, 62 (1975).PubMedGoogle Scholar
  2. 2.
    D.E. Cassels, in: The ductus Arteriosus, p.75. Charles C. Thomas Publisher, Springfield 1973.Google Scholar
  3. 3.
    M. Ikeda, E.H. Rubinstein and R.R. Sonnenschein, Proc. Soc. exp. Biol. Med.143, 354 (1973).PubMedGoogle Scholar
  4. 4.
    G.S. Dawes, in: Foetal and Neonatal Physiology, p. 184. Year Book Medical Publisher, Chicago 1969.Google Scholar
  5. 5.
    G.V.R. Born, G.S. Dawes, J.C. Mott and B.R. Rennick, J. Physiol.132, 304 (1956).PubMedGoogle Scholar
  6. 6.
    W.M. Bayliss, J. Physiol.28, 220 (1902).Google Scholar
  7. 7.
    V. Kovalčik, J. Physiol.169, 185 (1963).PubMedGoogle Scholar
  8. 8.
    M. Krigka and V. Kovalčik, Folia Fac. reed. Univ. Com. Bratisl.11, 145 (1973).Google Scholar
  9. 9.
    J.A. Kennedy and S. L. Clark, Anat. Rec.79, 349 (1941).CrossRefGoogle Scholar
  10. 10.
    R.G. Gillman and A.C. Burton, Circulation Res.19, 755 (1966).PubMedGoogle Scholar
  11. 11.
    T.W. McIntyre, Biophys. J.9, 685 (1969).PubMedGoogle Scholar

Copyright information

© Birkhäuser-Verlag 1978

Authors and Affiliations

  • V. Smieško
    • 1
    • 2
  • M. Kriška
    • 1
    • 2
  • V. Kovalčík
    • 1
    • 2
  1. 1.Institute of Normal and Pathological PhysiologySlovak Academy of Sciences(Czechoslovakia)
  2. 2.Department of PharmacologyKomensky University Medical SchoolBratislava(Czechoslovakia)

Personalised recommendations